Alterations in the serum metabolome in patients with the COVID-19 Omicron variant and in recovered cases

Feng Gao; Daming Wang; Lihua Zuo; Junyi Sun; Bowen Dong; Ranran Sun; Yingying Shi; Ying Sun; Yawen Zou; Qingquan Jia; Na Han; Haiyu Wang; Liwen Liu; Guizhen Zhang; Zujiang Yu; Zhi Sun; Zhigang Ren

doi:10.1371/journal.pone.0327297

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Open Access

Peer-reviewed

Research Article

Alterations in the serum metabolome in patients with the COVID-19 Omicron variant and in recovered cases

Feng Gao ,

Contributed equally to this work with: Feng Gao, Daming Wang, Lihua Zuo

Roles Data curation, Software, Writing – original draft

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Daming Wang ,

Contributed equally to this work with: Feng Gao, Daming Wang, Lihua Zuo

Roles Data curation, Writing – review & editing

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Lihua Zuo ,

Contributed equally to this work with: Feng Gao, Daming Wang, Lihua Zuo

Roles Methodology, Software

Affiliation Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Junyi Sun,

Roles Data curation, Writing – review & editing

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Bowen Dong,

Roles Data curation

Affiliation Department of Translational Medicine Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Ranran Sun,

Roles Data curation, Validation

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Yingying Shi,

Roles Methodology, Software

Affiliation Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Ying Sun,

Roles Data curation

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Yawen Zou,

Roles Data curation

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Qingquan Jia,

Roles Software

Affiliation Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Na Han,

Roles Resources

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Haiyu Wang,

Roles Validation, Writing – review & editing

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Liwen Liu,

Roles Data curation

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Guizhen Zhang,

Roles Data curation

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Zujiang Yu,

Roles Conceptualization, Validation, Writing – review & editing

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
Zhi Sun ,

Roles Methodology, Software

* E-mail: fccrenzg@zzu.edu.cn (ZR); sunzhi2013@163.com (ZH)

Affiliation Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China
⨯
[ ... ],
Zhigang Ren

Roles Conceptualization, Writing – review & editing

* E-mail: fccrenzg@zzu.edu.cn (ZR); sunzhi2013@163.com (ZH)

Affiliation Department of Infectious Diseases, State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China

https://orcid.org/0000-0003-0798-3444

⨯
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Alterations in the serum metabolome in patients with the COVID-19 Omicron variant and in recovered cases

Feng Gao,
Daming Wang,
Lihua Zuo,
Junyi Sun,
Bowen Dong,
Ranran Sun,
Yingying Shi,
Ying Sun,
Yawen Zou,
Qingquan Jia

Published: October 14, 2025
https://doi.org/10.1371/journal.pone.0327297

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