Resveratrol aggravated H2O2-induced the HK-2 cell damage by inhibiting AKT phosphorylation

Shicheng Luo; Yuning Chen; Xuyi Ma; Feng Tian; Xiaozhou He

doi:10.1371/journal.pone.0327135

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Open Access

Peer-reviewed

Research Article

Resveratrol aggravated H₂O₂-induced the HK-2 cell damage by inhibiting AKT phosphorylation

Shicheng Luo ,

Contributed equally to this work with: Shicheng Luo, Yuning Chen, Xuyi Ma

Roles Conceptualization, Data curation, Investigation, Project administration, Resources, Writing – original draft

Affiliations Department of Urology, The Affiliated Lianyungang Municipal Oriental Hospital of Xuzhou Medical University, Lianyungang, Jiangsu Province, China, Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China

https://orcid.org/0000-0001-5776-1319

⨯
Yuning Chen ,

Contributed equally to this work with: Shicheng Luo, Yuning Chen, Xuyi Ma

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Software, Supervision, Writing – review & editing

Affiliation Changzhou Center for Disease Control and Prevention, Changzhou, Jiangsu Province, China
⨯
Xuyi Ma ,

Contributed equally to this work with: Shicheng Luo, Yuning Chen, Xuyi Ma

Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software

Affiliation Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China
⨯
Feng Tian ,

Roles Formal analysis, Investigation, Resources, Software, Validation

* E-mail: hxz19592024@163.com (XH); 15261379506@163.com (FT)

Affiliation Department of Urology, The Affiliated Lianyungang Municipal Oriental Hospital of Xuzhou Medical University, Lianyungang, Jiangsu Province, China
⨯
Xiaozhou He

Roles Data curation, Funding acquisition, Investigation, Supervision, Writing – review & editing

* E-mail: hxz19592024@163.com (XH); 15261379506@163.com (FT)

Affiliation Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, China
⨯

Resveratrol aggravated H₂O₂-induced the HK-2 cell damage by inhibiting AKT phosphorylation

Shicheng Luo,
Yuning Chen,
Xuyi Ma,
Feng Tian,
Xiaozhou He

Published: July 31, 2025
https://doi.org/10.1371/journal.pone.0327135

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