Integrating network pharmacology and experimental verification to explore the protective effects of Evodia rutaecarpa in ischemic stroke

Zhixuan Huang; Jian Liu; Hui Li; Hengjun Huang; Yangwen Ai; Dongyue Zhou

doi:10.1371/journal.pone.0327133

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Open Access

Peer-reviewed

Research Article

Integrating network pharmacology and experimental verification to explore the protective effects of Evodia rutaecarpa in ischemic stroke

Zhixuan Huang,

Roles Funding acquisition, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, China, Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, China
⨯
Jian Liu,

Roles Investigation, Methodology, Writing – original draft

Affiliations Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, China, Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, China
⨯
Hui Li,

Roles Investigation, Resources, Supervision

Affiliations Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, China, Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, China, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
⨯
Hengjun Huang,

Roles Investigation, Resources, Supervision

Affiliations Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, China, Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, China
⨯
Yangwen Ai ,

Roles Conceptualization, Funding acquisition, Supervision

* E-mail: aiyangwen@itcmhi.ac.cn (YA); zhoudongyue@itcmhi.ac.cn (DZ)

Affiliations Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, China, Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, China
⨯
Dongyue Zhou

Roles Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: aiyangwen@itcmhi.ac.cn (YA); zhoudongyue@itcmhi.ac.cn (DZ)

Affiliations Jiangxi Province Key Laboratory of Traditional Chinese Medicine Pharmacology, Institute of Traditional Chinese Medicine Health Industry, China Academy of Chinese Medical Sciences, Nanchang, China, Jiangxi Health Industry Institute of Traditional Chinese Medicine, Nanchang, China

https://orcid.org/0009-0004-3857-2992

⨯

Integrating network pharmacology and experimental verification to explore the protective effects of Evodia rutaecarpa in ischemic stroke

Zhixuan Huang,
Jian Liu,
Hui Li,
Hengjun Huang,
Yangwen Ai,
Dongyue Zhou

Published: June 27, 2025
https://doi.org/10.1371/journal.pone.0327133

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