Application of video surveillance in preclinical safety studies in canines: Understanding the interobserver reliability and validity to recognize clinical behavior

Eline Eberhardt; Fetene Tekle; Greet Teuns; Jill Witters; Bianca Feyen; Sarah De Landtsheer; Ivan Kopljar

doi:10.1371/journal.pone.0326916

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Open Access

Peer-reviewed

Research Article

Application of video surveillance in preclinical safety studies in canines: Understanding the interobserver reliability and validity to recognize clinical behavior

Eline Eberhardt,

Roles Data curation, Formal analysis, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliation Nonclinical Safety & Submissions, Preclinical Sciences and Translational Safety, Johnson & Johnson Innovative Medicine R&D, Beerse, Belgium
⨯
Fetene Tekle,

Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Writing – review & editing

Affiliation Statistics & Decision Sciences, JRD Global Development, Johnson & Johnson Innovative Medicine R&D, Beerse, Belgium
⨯
Greet Teuns,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliation Translational Pharmacokinetics Pharmacodynamics & Investigational Toxicology, Preclinical Sciences and Translational Safety, Johnson & Johnson Innovative Medicine R&D, Beerse, Belgium
⨯
Jill Witters,

Roles Conceptualization, Investigation, Methodology

Affiliation Scientific & In vivo Strategies, Preclinical Sciences and Translational Safety, Johnson & Johnson Innovative Medicine R&D, Beerse, Belgium
⨯
Bianca Feyen,

Roles Investigation, Resources, Writing – review & editing

Affiliation Nonclinical Safety & Submissions, Preclinical Sciences and Translational Safety, Johnson & Johnson Innovative Medicine R&D, Beerse, Belgium
⨯
Sarah De Landtsheer,

Roles Investigation, Resources, Writing – review & editing

Affiliation Scientific & In vivo Strategies, Preclinical Sciences and Translational Safety, Johnson & Johnson Innovative Medicine R&D, Beerse, Belgium
⨯
Ivan Kopljar

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: IKopljar@its.jnj.com

Affiliation Nonclinical Safety & Submissions, Preclinical Sciences and Translational Safety, Johnson & Johnson Innovative Medicine R&D, Beerse, Belgium

https://orcid.org/0000-0003-4603-2238

⨯

Application of video surveillance in preclinical safety studies in canines: Understanding the interobserver reliability and validity to recognize clinical behavior

Eline Eberhardt,
Fetene Tekle,
Greet Teuns,
Jill Witters,
Bianca Feyen,
Sarah De Landtsheer,
Ivan Kopljar

Published: June 27, 2025
https://doi.org/10.1371/journal.pone.0326916

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