Comprehensive multi-omics analysis reveals the prognostic and immune regulatory characteristics of the PTPN family in osteosarcoma

Changhai Long; Biao Ma; Xingshun Zhong; Mingzhi Zou; Kai Li; Sijing Liu

doi:10.1371/journal.pone.0326872

Loading metrics

Open Access

Peer-reviewed

Research Article

Comprehensive multi-omics analysis reveals the prognostic and immune regulatory characteristics of the PTPN family in osteosarcoma

Changhai Long ,

Contributed equally to this work with: Changhai Long, Biao Ma

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Orthopaedics, Guangdong Medical University Affiliated Second Hospital, Zhanjiang, Guangdong, China
⨯
Biao Ma ,

Contributed equally to this work with: Changhai Long, Biao Ma

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Orthopaedics, Guangdong Medical University Affiliated Second Hospital, Zhanjiang, Guangdong, China
⨯
Xingshun Zhong,

Roles Formal analysis

Affiliation Department of Orthopaedics, Guangdong Medical University Affiliated Second Hospital, Zhanjiang, Guangdong, China
⨯
Mingzhi Zou ,

Roles Software

* E-mail: lsjlm808@163.com (SJL); kai257257@outlook.com (KL); zmz18966@163.com (MZZ)

Affiliation Department of Pharmacy, Guangdong Medical University Affiliated Second Hospital, Zhanjiang, Guangdong, China
⨯
Kai Li ,

Roles Investigation

* E-mail: lsjlm808@163.com (SJL); kai257257@outlook.com (KL); zmz18966@163.com (MZZ)

Affiliation Department of Orthopaedics, Guangdong Medical University Affiliated Second Hospital, Zhanjiang, Guangdong, China
⨯
Sijing Liu

Roles Project administration

* E-mail: lsjlm808@163.com (SJL); kai257257@outlook.com (KL); zmz18966@163.com (MZZ)

Affiliations Department of Orthopaedics, Guangdong Medical University Affiliated Second Hospital, Zhanjiang, Guangdong, China, Department of Joint Surgery II, Maoming Hospital of Guangzhou University of Chinese Medicine, Maoming, Guangdong, China

https://orcid.org/0000-0001-5249-0572

⨯

Comprehensive multi-omics analysis reveals the prognostic and immune regulatory characteristics of the PTPN family in osteosarcoma

Changhai Long,
Biao Ma,
Xingshun Zhong,
Mingzhi Zou,
Kai Li,
Sijing Liu

Published: June 26, 2025
https://doi.org/10.1371/journal.pone.0326872

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cytotoxic T cells
Is the Subject Area "Cytotoxic T cells" applicable to this article?

Thanks for your feedback.
Osteosarcoma
Is the Subject Area "Osteosarcoma" applicable to this article?

Thanks for your feedback.
Gene expression
Is the Subject Area "Gene expression" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Regulatory T cells
Is the Subject Area "Regulatory T cells" applicable to this article?

Thanks for your feedback.
Malignant tumors
Is the Subject Area "Malignant tumors" applicable to this article?

Thanks for your feedback.
Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
CD coreceptors
Is the Subject Area "CD coreceptors" applicable to this article?

Thanks for your feedback.