In vitro 3D drug sensitivity testing for patient-derived tumor-like cell clusters and whole-exome sequencing to personalize postoperative treatment: A study protocol for a multicenter randomized controlled trial

• Xiaoyuan Qiu ,

  Contributed equally to this work with: Xiaoyuan Qiu, Ruiqiang Li

  Roles Data curation, Writing – original draft

  Affiliation Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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• Ruiqiang Li ,

  Contributed equally to this work with: Xiaoyuan Qiu, Ruiqiang Li

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – original draft

  Affiliation GeneX Health Company Limited Laboratory, Beijing, China

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• Gengchen Xie,

  Roles Conceptualization, Project administration, Resources, Supervision

  Affiliation Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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• Ning Ning,

  Roles Conceptualization, Project administration, Resources, Validation

  Affiliation Department of Gastrointestinal Surgery, Peking University International Hospital, Beijing, China

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• Zhenjun Wang,

  Roles Project administration, Resources, Supervision

  Affiliation Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

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• Jiaolin Zhou,

  Roles Conceptualization, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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• Ge Liu,

  Roles Project administration, Resources, Supervision

  Affiliation Department of General Surgery, The First Affiliated Hospital, Dalian Medical University, Dalian, China

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• Qingchao Tang,

  Roles Methodology, Resources, Supervision

  Affiliation Department of Center of Cancer, Colorectal Oncological Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China

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• Zhuo He,

  Roles Investigation, Project administration, Resources

  Affiliation Department of Gastroduodenal and Pancreatic Surgery, Hunan Cancer Hospital, Affiliated Cancer Hospital of Xiangya Medical School, Central South University, Changsha, China

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• Leilei Yang,

  Roles Conceptualization, Methodology, Validation

  Affiliation GeneX Health Company Limited Laboratory, Beijing, China

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• Junyang Lu,

  Roles Data curation, Formal analysis

  Affiliation Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

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• Peng Li ,

  Roles Conceptualization, Data curation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: linguole@126.com (GL); doctorlipeng@126.com (PL)

  Affiliation Department of General Surgery, First Medical Center of Chinese People′s Liberation Army General Hospital, Beijing, China

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• Guole Lin

  Roles Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: linguole@126.com (GL); doctorlipeng@126.com (PL)

  Affiliation Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

  https://orcid.org/0000-0001-6225-3028

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