Rationale and study protocol of the MAMELI Cohort study (Mapping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a Living lab)

Valentina Bollati; Federica Rota; Laura Dioni; Chiara Favero; Simona Iodice; Marta Gallazzi; Andrea Spinazzè; Giacomo Fanti; Davide Campagnolo; Tiago Nardi; Davide Biganzoli; Eva Dariol; Rachele Matsagani; Mirjam Hoxha; Paola Monti; Benedetta Albetti; Letizia Tarantini; Davide Barbuto; Ester Luconi; Giuseppe Marano; Giacomo Biganzoli; Roberta Biciuffi; Patrizia Boracchi; Domenico M. Cavallo; Pilar M. Guerrieri; Fabio Mosca; Stefano Gustincich; Giovanni Sanesi; Luca Ferrari; Michele Carugno; Silvia Fustinoni; Angela Cecilia Pesatori; Luca Pandolfini; Michele Miragoli; Andrea Cattaneo; Elia Biganzoli

doi:10.1371/journal.pone.0326467

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Rationale and study protocol of the MAMELI Cohort study (Mapping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a Living lab)

Valentina Bollati ,

Roles Conceptualization, Investigation, Resources, Writing – original draft

* E-mail: valentina.bollati@unimi.it

Affiliations EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy, INES (Institute of Epigenetics for Smiles), Università degli Studi di Milano, Milan, Italy

https://orcid.org/0000-0002-0370-9598

⨯
Federica Rota,

Roles Methodology, Project administration, Writing – review & editing

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Laura Dioni,

Roles Data curation, Methodology, Writing – review & editing

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Chiara Favero,

Roles Data curation, Formal analysis

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Simona Iodice,

Roles Data curation, Formal analysis

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Marta Gallazzi,

Roles Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Andrea Spinazzè,

Roles Methodology

Affiliation Department of Science and High Technology, Università degli Studi dell’Insubria, Como, Italy

https://orcid.org/0000-0003-0371-3164

⨯
Giacomo Fanti,

Roles Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Davide Campagnolo,

Roles Methodology

Affiliation Department of Science and High Technology, Università degli Studi dell’Insubria, Como, Italy
⨯
Tiago Nardi,

Roles Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy

https://orcid.org/0000-0002-1248-9873

⨯
Davide Biganzoli,

Roles Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy

https://orcid.org/0000-0002-6509-6870

⨯
Eva Dariol,

Roles Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy

https://orcid.org/0009-0002-5675-3389

⨯
Rachele Matsagani,

Roles Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy

https://orcid.org/0000-0002-9625-1191

⨯
Mirjam Hoxha,

Roles Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Paola Monti,

Roles Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Benedetta Albetti,

Roles Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Letizia Tarantini,

Roles Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Davide Barbuto,

Roles Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Ester Luconi,

Roles Data curation, Methodology

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy

https://orcid.org/0000-0001-9912-9370

⨯
Giuseppe Marano,

Roles Data curation, Formal analysis

Affiliation Unit of Medical Statistics, Department of Biomedical and Clinical Sciences (DIBIC), LITA Vialba campus, Università degli Studi di Milano, Milan, Italy

https://orcid.org/0000-0002-0239-7297

⨯
Giacomo Biganzoli,

Roles Data curation, Formal analysis

Affiliation Unit of Medical Statistics, Department of Biomedical and Clinical Sciences (DIBIC), LITA Vialba campus, Università degli Studi di Milano, Milan, Italy
⨯
Roberta Biciuffi,

Roles Methodology

Affiliation Unit of Medical Statistics, Department of Biomedical and Clinical Sciences (DIBIC), LITA Vialba campus, Università degli Studi di Milano, Milan, Italy
⨯
Patrizia Boracchi,

Roles Data curation, Formal analysis

Affiliation Unit of Medical Statistics, Department of Biomedical and Clinical Sciences (DIBIC), LITA Vialba campus, Università degli Studi di Milano, Milan, Italy
⨯
Domenico M. Cavallo,

Roles Supervision, Writing – review & editing

Affiliation Department of Science and High Technology, Università degli Studi dell’Insubria, Como, Italy
⨯
Pilar M. Guerrieri,

Roles Investigation, Writing – original draft

Affiliation “Dipartimento di Architettura e Studi Urbani”, Politecnico di Milano, Milan, Italy
⨯
Fabio Mosca,

Roles Investigation, Writing – review & editing

Affiliation Università degli Studi di Milano, Milan, Italy
⨯
Stefano Gustincich,

Roles Investigation, Writing – review & editing

Affiliation Non-coding RNAs and RNA-based Therapeutics, Istituto Italiano di Tecnologia (IIT), Genova, Italy
⨯
Giovanni Sanesi,

Roles Investigation, Writing – original draft

Affiliation Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy
⨯
Luca Ferrari,

Roles Investigation

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Michele Carugno,

Roles Investigation

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Silvia Fustinoni,

Roles Investigation, Methodology

Affiliations EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy, Toxicology lab, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
⨯
Angela Cecilia Pesatori,

Roles Supervision, Writing – review & editing

Affiliation EPIGET Lab -Department of Clinical Sciences and Community Health, “Dipartimento di Eccellenza 2023-2027”, Università degli Studi di Milano, Milan, Italy
⨯
Luca Pandolfini,

Roles Data curation, Funding acquisition, Methodology, Writing – original draft

Affiliation Non-coding RNAs and RNA-based Therapeutics, Istituto Italiano di Tecnologia (IIT), Genova, Italy
⨯
Michele Miragoli,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Dipartimento di Medicina e Chirurgia, TecMed Lab, Università di Parma, Parma, Italy
⨯
Andrea Cattaneo,

Roles Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Department of Science and High Technology, Università degli Studi dell’Insubria, Como, Italy
⨯
[ ... ],
Elia Biganzoli

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – original draft

Affiliations INES (Institute of Epigenetics for Smiles), Università degli Studi di Milano, Milan, Italy, Unit of Medical Statistics, Department of Biomedical and Clinical Sciences (DIBIC), LITA Vialba campus, Università degli Studi di Milano, Milan, Italy
⨯
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Rationale and study protocol of the MAMELI Cohort study (Mapping the Methylation of repetitive elements to track the Exposome effects on health: the city of Legnano as a Living lab)

Valentina Bollati,
Federica Rota,
Laura Dioni,
Chiara Favero,
Simona Iodice,
Marta Gallazzi,
Andrea Spinazzè,
Giacomo Fanti,
Davide Campagnolo,
Tiago Nardi

Published: July 9, 2025
https://doi.org/10.1371/journal.pone.0326467
See the preprint

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