Longitudinal biomarker progression and validation for predicting operational tolerance in a prospective multicenter liver transplantation immunosuppression withdrawal trial

• Gloria López-Díaz ,

  Contributed equally to this work with: Gloria López-Díaz, María Isabel Sánchez-Lorencio

  Roles Investigation, Validation, Writing – review & editing

  ¶☯ These authors contributed equally and share first authorship to this work.

  Affiliation Hepatology and Liver Transplant Unit, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB-Pascual Parrilla), Murcia, Spain

  ⨯
• María Isabel Sánchez-Lorencio ,

  Contributed equally to this work with: Gloria López-Díaz, María Isabel Sánchez-Lorencio

  Roles Data curation, Formal analysis, Investigation

  ¶☯ These authors contributed equally and share first authorship to this work.

  Affiliation Molecular Inflammation Group, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB-Pascual Parrilla), Murcia, Spain

  ⨯
• Mercedes Iñarrairaegui,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Liver Unit, Clínica Universidad de Navarra, Pamplona, Spain, Instituto de Investigación Sanitaria de Navarra (IdiSNA), CIBERehd, Pamplona, Spain,

  ⨯
• María Luisa González-Diéguez,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Liver Unit, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain

  ⨯
• Valle Cadahía,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Liver Unit, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain

  ⨯
• Alejandra Otero-Ferreiro,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Liver Transplant Unit, Complejo Hospitalario A Coruña, A Coruña, Spain

  ⨯
• María Ángeles Vázquez-Millán,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Liver Transplant Unit, Complejo Hospitalario A Coruña, A Coruña, Spain

  ⨯
• Mario Romero-Cristóbal,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Liver Unit, H.G.U. Gregorio Marañón, Madrid, Spain, CIBERehd, Madrid, Spain,

  ⨯
• Magdalena Salcedo,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Liver Unit, H.G.U. Gregorio Marañón, Madrid, Spain, CIBERehd, Madrid, Spain,

  ⨯
• Sara Lorente-Pérez,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Liver Transplant Unit, Hospital Clínico Universitario Lozano Blesa, Universitiy of Zaragoza and ISS Aragón, Zaragoza, Spain

  ⨯
• Gloria Sánchez-Antolín,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Hepatology and Liver Transplant Unit, Hospital Universitario Río Hortega, Valladolid, Spain

  ⨯
• Jesús de la Peña,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Pathological Anatomy Unit, University Clinical Hospital Virgen de la Arrixaca, Murcia, Spain

  ⨯
• Pablo Ramírez,

  Roles Data curation, Formal analysis, Investigation

  Affiliation General Surgery Unit, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB-Pascual Parrilla), Murcia, Spain

  ⨯
• María P. Pata,

  Roles Data curation, Formal analysis, Methodology, Validation

  Affiliation Biostatech Advice, Training and Innovation in Biostatistics S.L., Santiago de Compostela, Spain

  ⨯
• Alberto Baroja-Mazo ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: joseapons.imib.arrixaca@gmail.com (JAP); alberto.baroja@ffis.es (AB-M)

  ¶‡ These authors share equal senior last authorship on this work.

  Affiliation Molecular Inflammation Group, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB-Pascual Parrilla), Murcia, Spain

  ⨯
• José I. Herrero ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  ¶‡ These authors share equal senior last authorship on this work.

  Affiliations Liver Unit, Clínica Universidad de Navarra, Pamplona, Spain, Instituto de Investigación Sanitaria de Navarra (IdiSNA), CIBERehd, Pamplona, Spain,

  https://orcid.org/0000-0002-9076-6717

  ⨯
•  [ ... ],
• José Antonio Pons

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: joseapons.imib.arrixaca@gmail.com (JAP); alberto.baroja@ffis.es (AB-M)

  ¶‡ These authors share equal senior last authorship on this work.

  Affiliations Hepatology and Liver Transplant Unit, University Clinical Hospital Virgen de la Arrixaca, Biomedical Research Institute of Murcia (IMIB-Pascual Parrilla), Murcia, Spain, Internal Medicine Department, Faculty of Medicine, University of Murcia, Campus de Ciencias de la Salud, Murcia, Spain

  https://orcid.org/0000-0001-5017-7240

  ⨯
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