Shared and distinct microRNA profiles between HT22, N2A and SH-SY5Y cell lines and primary mouse hippocampal neurons

Ronan Murphy; Javier Villegas-Salmerón; Amaya Sanz-Rodriguez; Tobias Engel; Catherine Mooney; David C. Henshall; Eva M. Jimenez-Mateos

doi:10.1371/journal.pone.0326401

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Open Access

Peer-reviewed

Research Article

Shared and distinct microRNA profiles between HT22, N2A and SH-SY5Y cell lines and primary mouse hippocampal neurons

Ronan Murphy,

Roles Formal analysis, Investigation

Affiliation Discipline of Physiology, School of Medicine, Trinity College Dublin, The University of Dublin, Dublin, Ireland
⨯
Javier Villegas-Salmerón,

Affiliations Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland, FutureNeuro Research Ireland Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland, The SFI Centre for Research Training in Genomics Data Science, RCSI University of Medicine & Health Sciences, Dublin, Ireland
⨯
Amaya Sanz-Rodriguez,

Roles Investigation

Affiliations Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland, FutureNeuro Research Ireland Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland
⨯
Tobias Engel,

Roles Methodology

Affiliations Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland, FutureNeuro Research Ireland Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland
⨯
Catherine Mooney,

Roles Methodology

Affiliations FutureNeuro Research Ireland Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland, School of Computer Science, University College Dublin, Dublin, Ireland

https://orcid.org/0000-0002-7696-1364

⨯
David C. Henshall ,

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: dhenshall@rcsi.ie (DCH); jimeneze@tcd.ie (EMJ-M)

Affiliations Department of Physiology and Medical Physics, RCSI University of Medicine and Health Sciences, Dublin, Ireland, FutureNeuro Research Ireland Centre, RCSI University of Medicine and Health Sciences, Dublin, Ireland
⨯
Eva M. Jimenez-Mateos

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: dhenshall@rcsi.ie (DCH); jimeneze@tcd.ie (EMJ-M)

Affiliation Discipline of Physiology, School of Medicine, Trinity College Dublin, The University of Dublin, Dublin, Ireland

https://orcid.org/0000-0001-6417-6580

⨯

Shared and distinct microRNA profiles between HT22, N2A and SH-SY5Y cell lines and primary mouse hippocampal neurons

Ronan Murphy,
Javier Villegas-Salmerón,
Amaya Sanz-Rodriguez,
Tobias Engel,
Catherine Mooney,
David C. Henshall,
Eva M. Jimenez-Mateos

Published: December 3, 2025
https://doi.org/10.1371/journal.pone.0326401

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MicroRNAs
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