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Open Access
Peer-reviewed
Research Article
The impact of experimental designs & system sloppiness on the personalisation process: A cardiovascular perspective
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Harry Saxton ,
Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft
* E-mail: h.saxton@sheffield.ac.uk
Affiliations School of Computer Science, University of Sheffield, Sheffield, United Kingdom, Insigneo Institute for in-silico Medicine, University of Sheffield, Sheffield, United Kingdom
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Daniel J. Taylor,
Roles Conceptualization, Methodology, Writing – original draft
Affiliations Insigneo Institute for in-silico Medicine, University of Sheffield, Sheffield, United Kingdom, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom, NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
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Grace Faulkner,
Roles Visualization, Writing – review & editing
Affiliations Insigneo Institute for in-silico Medicine, University of Sheffield, Sheffield, United Kingdom, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom, NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom
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Ian Halliday,
Roles Conceptualization, Funding acquisition, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliations Insigneo Institute for in-silico Medicine, University of Sheffield, Sheffield, United Kingdom, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom
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Tom Newman,
Roles Methodology
Affiliations Insigneo Institute for in-silico Medicine, University of Sheffield, Sheffield, United Kingdom, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom, NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, Department of Cardiology and Cardiothoracic Surgery, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom
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Torsten Schenkel,
Roles Funding acquisition, Software, Supervision, Writing – original draft
Affiliations Department of Cardiology and Cardiothoracic Surgery, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom, Department of Engineering and Mathematics, Sheffield Hallam University, Sheffield, United Kingdom
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Paul D. Morris,
Roles Writing – review & editing
Affiliations Insigneo Institute for in-silico Medicine, University of Sheffield, Sheffield, United Kingdom, Division of Clinical Medicine, School of Medicine and Population Health, University of Sheffield, Sheffield, United Kingdom, NIHR Sheffield Biomedical Research Centre, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, United Kingdom, Department of Cardiology and Cardiothoracic Surgery, Sheffield Teaching Hospitals NHS Trust, Sheffield, United Kingdom
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Richard H. Clayton,
Roles Supervision, Writing – review & editing
Affiliations School of Computer Science, University of Sheffield, Sheffield, United Kingdom, Insigneo Institute for in-silico Medicine, University of Sheffield, Sheffield, United Kingdom
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Xu Xu
Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing
Affiliations School of Computer Science, University of Sheffield, Sheffield, United Kingdom, Insigneo Institute for in-silico Medicine, University of Sheffield, Sheffield, United Kingdom
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The impact of experimental designs & system sloppiness on the personalisation process: A cardiovascular perspective
- Harry Saxton,
- Daniel J. Taylor,
- Grace Faulkner,
- Ian Halliday,
- Tom Newman,
- Torsten Schenkel,
- Paul D. Morris,
- Richard H. Clayton,
- Xu Xu
- Published: June 24, 2025
- https://doi.org/10.1371/journal.pone.0326112