Metformin modulates the unfolded protein responses, altering lifespan and health-promoting effects in UPR-activated worms

• Jerald Tan ,

  Contributed equally to this work with: Jerald Tan, Chutipong Chiamkunakorn

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

  https://orcid.org/0000-0002-3462-3455

  ⨯
• Chutipong Chiamkunakorn ,

  Contributed equally to this work with: Jerald Tan, Chutipong Chiamkunakorn

  Roles Data curation, Formal analysis, Investigation, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: wichit.sut@mahidol.edu (WS); pong.chutipong@gmail.com (CC)

  Affiliation Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

  ⨯
• Kanpapat Boonchuay,

  Roles Data curation, Investigation, Project administration

  Affiliation Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

  https://orcid.org/0000-0001-5140-429X

  ⨯
• Yiying Shi,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

  ⨯
• Bart P. Braeckman,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Biology, Ghent University, Ghent, Belgium

  ⨯
• Wichit Suthammarak

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  * E-mail: wichit.sut@mahidol.edu (WS); pong.chutipong@gmail.com (CC)

  Affiliation Department of Biochemistry, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand

  https://orcid.org/0000-0002-1525-7533

  ⨯