Epac1 increases myosin regulatory light-chain phosphorylation, energetic cost of contraction, and susceptibility to heart failure

• Yoshiki Ohnuki,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft

  Affiliations Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan, Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan

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• Kenji Suita,

  Roles Funding acquisition, Investigation

  Affiliations Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan, Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan

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• Misao Ishikawa,

  Roles Investigation

  Affiliation Department of Oral Anatomy, Tsurumi University School of Dental Medicine, Yokohama, Japan

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• Yasumasa Mototani,

  Roles Investigation

  Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

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• Megumi Nariyama,

  Roles Funding acquisition, Investigation

  Affiliation Department of Pediatric Dentistry, Tsurumi University School of Dental Medicine, Yokohama, Japan

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• Aiko Ito,

  Roles Funding acquisition, Investigation

  Affiliation Department of Orthodontics, Tsurumi University School of Dental Medicine, Yokohama, Japan

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• Ichiro Matsuo,

  Roles Investigation

  Affiliations Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan, Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan, Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan

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• Yoshio Hayakawa,

  Roles Investigation

  Affiliation Department of Dental Anesthesiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

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• Akinaka Morii,

  Roles Investigation

  Affiliations Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan, Department of Periodontology, Tsurumi University School of Dental Medicine, Yokohama, Japan

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• Takao Mitsubayashi,

  Roles Investigation

  Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

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• Yasutake Saeki,

  Roles Methodology

  Affiliation Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan

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• Yoshihiro Ishikawa,

  Roles Conceptualization

  Affiliation Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan

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• Satoshi Okumura

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft

  * E-mail: okumura-s@tsurumi-u.ac.jp

  Affiliations Department of Physiology, Tsurumi University School of Dental Medicine, Yokohama, Japan, Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan

  https://orcid.org/0000-0001-8747-7941

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