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Open Access
Peer-reviewed
Research Article
Detectable SARS-CoV-2 specific immune responses in recovered unvaccinated individuals 250 days post wild type infection
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Nikolas Weigl ,
Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – original draft, Writing – review & editing
¶Member of the German Center for Lung Research (DZL).
¶☯ These authors contributed equally to this work and share first authorship.
Affiliation Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany, Member of the German Center for Lung Research (DZL)
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Claire Pleimelding ,
Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing
¶☯ These authors contributed equally to this work and share first authorship.
Affiliation Department of Infectious Diseases, LMU University Hospital, LMU Munich, Munich, Germany
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Leonard Gilberg,
Roles Data curation, Investigation, Writing – original draft, Writing – review & editing
Affiliation Department of Infectious Diseases, LMU University Hospital, LMU Munich, Munich, Germany
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Duc Huynh ,
Roles Data curation, Formal analysis, Methodology, Supervision
¶Member of the German Center for Lung Research (DZL).
Affiliation Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany, Member of the German Center for Lung Research (DZL)
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Isabel Brand ,
Roles Data curation, Investigation
¶Member of the German Center for Lung Research (DZL).
Affiliation Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany, Member of the German Center for Lung Research (DZL)
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Jan Bruger,
Roles Data curation, Investigation
Affiliation Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany
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Jonathan Frese,
Roles Investigation
Affiliation Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany
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Tabea M. Eser,
Roles Investigation
Affiliations Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany
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Mohamed I. M. Ahmed,
Roles Investigation
Affiliation Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany
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Jessica M. Guggenbuehl-Noller,
Roles Investigation
Affiliation Department of Infectious Diseases, LMU University Hospital, LMU Munich, Munich, Germany
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Renate Stirner,
Roles Investigation, Methodology, Supervision
Affiliation Department of Infectious Diseases, LMU University Hospital, LMU Munich, Munich, Germany
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Michael Hoelscher,
Roles Funding acquisition, Resources
Affiliations Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany, German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany
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Michael Pritsch,
Roles Funding acquisition, Investigation, Resources, Supervision
Affiliations Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany, German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany
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Christof Geldmacher,
Roles Funding acquisition, Supervision, Writing – original draft, Writing – review & editing
Affiliations Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany, Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany, German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany
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Sebastian Kobold ,
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: Julia.roider@med.uni-muenchen.de (JR); Sebastian.kobold@med.uni-muenchen.de (SK)
¶Member of the German Center for Lung Research (DZL).
¶‡ SK and JR contributed equally to this work and share last authorship.
Affiliations Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany, Member of the German Center for Lung Research (DZL), German Cancer Consortium (DKTK), Partner Site Munich, a partnership between the DKFZ Heidelberg and the LMU University Hospital, Munich, Germany, Helmholtz Zentrum München, Research Center for Environmental Health (HMGU), Neuherberg, Germany,
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Julia Roider ,
Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: Julia.roider@med.uni-muenchen.de (JR); Sebastian.kobold@med.uni-muenchen.de (SK)
¶‡ SK and JR contributed equally to this work and share last authorship.
Affiliations Department of Infectious Diseases, LMU University Hospital, LMU Munich, Munich, Germany, German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany
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on behalf of the KoCo19-/ORCHESTRA-study group
¶Membership of the KoCo19-/ORCHESTRA-study group is provided in the Acknowledgments.
Affiliation Division of Clinical Pharmacology, Department of Medicine IV, LMU University Hospital, LMU Munich, Munich, Germany, Member of the German Center for Lung Research (DZL)
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Detectable SARS-CoV-2 specific immune responses in recovered unvaccinated individuals 250 days post wild type infection
- Nikolas Weigl,
- Claire Pleimelding,
- Leonard Gilberg,
- Duc Huynh,
- Isabel Brand,
- Jan Bruger,
- Jonathan Frese,
- Tabea M. Eser,
- Mohamed I. M. Ahmed,
- Jessica M. Guggenbuehl-Noller
- Published: June 11, 2025
- https://doi.org/10.1371/journal.pone.0325923