Retrospective challenges to pre-exposure prophylaxis (PrEP) use among people living with HIV—A qualitative analysis using the COM-B framework

Carina Hörst; Hannah Kitt; Helen Corkin; Dolores Mullen; Ammi Shah; Adamma Aghaizu; Clare Humphreys; Tamara Djuretic

doi:10.1371/journal.pone.0325871

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Open Access

Peer-reviewed

Research Article

Retrospective challenges to pre-exposure prophylaxis (PrEP) use among people living with HIV—A qualitative analysis using the COM-B framework

Carina Hörst ,

Roles Formal analysis, Methodology, Project administration, Writing – original draft, Writing – review & editing

* E-mail: carina.hoerst@ukhsa.gov.uk

Affiliation Blood Safety, Hepatitis, STI & HIV Division (BSHSH), UK Health Security Agency, London, United Kingdom

https://orcid.org/0000-0003-2053-7502

⨯
Hannah Kitt,

Roles Formal analysis, Writing – review & editing

Affiliation Blood Safety, Hepatitis, STI & HIV Division (BSHSH), UK Health Security Agency, London, United Kingdom

https://orcid.org/0009-0000-3983-1360

⨯
Helen Corkin,

Roles Investigation, Writing – review & editing

Affiliation Blood Safety, Hepatitis, STI & HIV Division (BSHSH), UK Health Security Agency, London, United Kingdom
⨯
Dolores Mullen,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Blood Safety, Hepatitis, STI & HIV Division (BSHSH), UK Health Security Agency, London, United Kingdom
⨯
Ammi Shah,

Roles Data curation, Writing – review & editing

Affiliation Blood Safety, Hepatitis, STI & HIV Division (BSHSH), UK Health Security Agency, London, United Kingdom
⨯
Adamma Aghaizu,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Blood Safety, Hepatitis, STI & HIV Division (BSHSH), UK Health Security Agency, London, United Kingdom
⨯
Clare Humphreys ,

Contributed equally to this work with: Clare Humphreys, Tamara Djuretic

Roles Supervision, Writing – review & editing

Affiliation UK Health Security Agency South East, Chilton, United Kingdom
⨯
Tamara Djuretic

Contributed equally to this work with: Clare Humphreys, Tamara Djuretic

Roles Supervision, Writing – review & editing

Affiliation Blood Safety, Hepatitis, STI & HIV Division (BSHSH), UK Health Security Agency, London, United Kingdom
⨯

Retrospective challenges to pre-exposure prophylaxis (PrEP) use among people living with HIV—A qualitative analysis using the COM-B framework

Carina Hörst,
Hannah Kitt,
Helen Corkin,
Dolores Mullen,
Ammi Shah,
Adamma Aghaizu,
Clare Humphreys,
Tamara Djuretic

Published: February 13, 2026
https://doi.org/10.1371/journal.pone.0325871

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HIV prevention
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HIV
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HIV diagnosis and management
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Medical risk factors
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Pre-exposure prophylaxis
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