The influence of hydrogel stiffness on axonal regeneration after spinal cord injury

Haiyang Deng; Jiaqing Zhou; Cong Long; Ping Luo; Zhong Xiang; Hao Zeng

doi:10.1371/journal.pone.0325798

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Open Access

Peer-reviewed

Research Article

The influence of hydrogel stiffness on axonal regeneration after spinal cord injury

Haiyang Deng,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Writing – original draft, Writing – review & editing

Affiliation Department of Spinal Surgery, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University), Changsha, Hunan, China
⨯
Jiaqing Zhou,

Roles Conceptualization, Methodology, Visualization

Affiliation Department of Spinal Surgery, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University), Changsha, Hunan, China
⨯
Cong Long,

Roles Methodology, Supervision, Visualization

Affiliation Department of Spinal Surgery, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University), Changsha, Hunan, China
⨯
Ping Luo,

Roles Investigation, Supervision, Writing – original draft

Affiliation Department of Spinal Surgery, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University), Changsha, Hunan, China
⨯
Zhong Xiang,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Spinal Surgery, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital of Changsha, Changsha Hospital of Hunan Normal University), Changsha, Hunan, China
⨯
Hao Zeng

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: 2621132371@qq.com

Affiliation Department of Spine Surgery Zone 2, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, China

https://orcid.org/0009-0004-9860-5901

⨯

The influence of hydrogel stiffness on axonal regeneration after spinal cord injury

Haiyang Deng,
Jiaqing Zhou,
Cong Long,
Ping Luo,
Zhong Xiang,
Hao Zeng

Published: June 25, 2025
https://doi.org/10.1371/journal.pone.0325798

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Gels
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Spinal cord injury
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Stiffness
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Nerve regeneration
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Extracellular matrix
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Spinal cord
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Regeneration
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Neurons
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