Hepatoprotective action of Sonchus oleraceus against paracetamol-induced toxicity via Nrf2/KEAP-1/HO-1 pathway in relation to its metabolite fingerprint and in silico studies

• Mohamed F. Abdelhameed,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Pharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, 33 El Bohouth St., Dokki, Cairo, Egypt

  https://orcid.org/0000-0001-6100-6498

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• Marawan A. El-Baset,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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• Amira R. Khattab,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Pharmacognosy Department, College of Pharmacy, Arab Academy for Science, Technology and Maritime Transport, Alexandria, Egypt

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• Rehab F. Taher,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Natural Compounds Chemistry, National Research Center, 33 El Bohouth St., Dokki, Giza, Egypt

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• Mohamed A. El-Saied,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Pathology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt

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• Asmaa S. Abd Elkarim,

  Roles Investigation, Methodology, Writing – original draft

  Affiliation Chemistry of Tanning Materials and Leather Technology Department, National Research Centre, 33 El Bohouth St., Dokki, Giza, Egypt

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• Ahmed F. Essa,

  Roles Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliation Department of Natural Compounds Chemistry, National Research Center, 33 El Bohouth St., Dokki, Giza, Egypt

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• Ahmed A. El-Rashedy,

  Roles Methodology, Writing – original draft

  Affiliations Chemistry of Natural and Microbial Products Department, National Research Centre, 33 El Bohouth St., Dokki, Giza, Egypt, Department Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Menoufia, Egypt

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• Mohamed A. Farag ,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  * E-mail: elshamynrc@yahoo.com (A.I. E.); aibrahim2@ksu.edu.sa (A.M.A-E.)

  Affiliations Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt, Faculty of Healthcare, Saxony Egypt University (SEU), Badr city, Egypt

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• Hiroshi Imagawa,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliation Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770, Japan

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• Abdelsamed I. Elshamy ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  * E-mail: elshamynrc@yahoo.com (A.I. E.); aibrahim2@ksu.edu.sa (A.M.A-E.)

  Affiliations Department of Natural Compounds Chemistry, National Research Center, 33 El Bohouth St., Dokki, Giza, Egypt, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima, 770, Japan

  https://orcid.org/0000-0003-3302-3623

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• Ahmed M. Abd-ElGawad

  Roles Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: elshamynrc@yahoo.com (A.I. E.); aibrahim2@ksu.edu.sa (A.M.A-E.)

  Affiliation Plant Production Department, College of Food & Agriculture Sciences, King Saud University, P.O. Box 2460, Riyadh 11451, Saudi Arabia

  https://orcid.org/0000-0002-5903-6329

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