Mechanism of Plantamajoside in inhibiting ferroptosis of pancreatic β cells and treatment of T2DM via activation of the xCT/GPX4 pathway

Hongmin Zhao; Renlin Li; Xuan Guo; Jingrui Kang; Huajun Li; Xiaoyun Wang; Yuansong Wang; Huantian Cui; Shuquan Lv; Weibo Wen; Zhongyong Zhang

doi:10.1371/journal.pone.0325674

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Open Access

Peer-reviewed

Research Article

Mechanism of Plantamajoside in inhibiting ferroptosis of pancreatic β cells and treatment of T2DM via activation of the xCT/GPX4 pathway

Hongmin Zhao ,

Roles Funding acquisition, Investigation, Writing – review & editing

¶‡ These authors share first authorship on this work.

Affiliation Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei, Hebei, China
⨯
Renlin Li ,

Roles Data curation, Investigation, Validation, Writing – original draft

¶‡ These authors share first authorship on this work.

Affiliation Yunnan University of Chinese Medicine, Kunming, China
⨯
Xuan Guo,

Roles Data curation, Investigation, Validation

Affiliation Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei, Hebei, China
⨯
Jingrui Kang,

Roles Data curation, Investigation, Validation

Affiliation Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei, Hebei, China
⨯
Huajun Li,

Roles Formal analysis, Visualization, Writing – original draft

Affiliation Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei, Hebei, China
⨯
Xiaoyun Wang,

Roles Formal analysis, Visualization, Writing – original draft

Affiliation Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei, Hebei, China
⨯
Yuansong Wang,

Roles Investigation, Validation

Affiliation Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei, Hebei, China
⨯
Huantian Cui,

Roles Investigation, Validation

Affiliation Yunnan University of Chinese Medicine, Kunming, China
⨯
Shuquan Lv ,

Roles Conceptualization, Data curation, Investigation, Writing – original draft

* E-mail: czlvshuquan@163.com (SL); wenweibo2020@163.com (WW); zzyhappy666@126.com (ZZ)

Affiliation Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei, Hebei, China
⨯
Weibo Wen ,

Roles Conceptualization, Writing – original draft

* E-mail: czlvshuquan@163.com (SL); wenweibo2020@163.com (WW); zzyhappy666@126.com (ZZ)

Affiliation Yunnan University of Chinese Medicine, Kunming, China

https://orcid.org/0000-0002-9303-7341

⨯
Zhongyong Zhang

Roles Data curation, Investigation, Writing – original draft

* E-mail: czlvshuquan@163.com (SL); wenweibo2020@163.com (WW); zzyhappy666@126.com (ZZ)

Affiliation Cangzhou Hospital of Integrated Traditional Chinese Medicine and Western Medicine of Hebei, Hebei, China
⨯

Mechanism of Plantamajoside in inhibiting ferroptosis of pancreatic β cells and treatment of T2DM via activation of the xCT/GPX4 pathway

Hongmin Zhao,
Renlin Li,
Xuan Guo,
Jingrui Kang,
Huajun Li,
Xiaoyun Wang,
Yuansong Wang,
Huantian Cui,
Shuquan Lv,
Weibo Wen

Published: June 20, 2025
https://doi.org/10.1371/journal.pone.0325674

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Type 2 diabetes
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Apoptosis
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