Effects of dapagliflozin on blood volume status and vascular outcomes in clinically stabilized heart failure patients after an acute decompensated heart failure event (DAPA-VOLVO study): Protocol of a double-blind randomized controlled clinical trial

Konstantinos Bitos; Natallia Laptseva; Thomas Haider; Valentina A. Rossi; Matthias P. Nägele; Jens Barthelmes; Frank Ruschitzka; Isabella Sudano; Andreas J. Flammer

doi:10.1371/journal.pone.0325668

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Effects of dapagliflozin on blood volume status and vascular outcomes in clinically stabilized heart failure patients after an acute decompensated heart failure event (DAPA-VOLVO study): Protocol of a double-blind randomized controlled clinical trial

Konstantinos Bitos ,

Roles Investigation, Project administration, Writing – original draft, Writing – review & editing

* E-mail: konstantinos.bitos@usz.ch

Affiliation Heart Failure and Heart Transplantation Unit, Department of Cardiology, University Heart Center Zurich, Zurich, Switzerland

https://orcid.org/0009-0002-2609-6330

⨯
Natallia Laptseva,

Roles Investigation, Project administration, Writing – review & editing

Affiliation Heart Failure and Heart Transplantation Unit, Department of Cardiology, University Heart Center Zurich, Zurich, Switzerland

https://orcid.org/0009-0008-6855-7768

⨯
Thomas Haider,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Heart Failure and Heart Transplantation Unit, Department of Cardiology, University Heart Center Zurich, Zurich, Switzerland
⨯
Valentina A. Rossi,

Roles Investigation, Writing – review & editing

Affiliation Heart Failure and Heart Transplantation Unit, Department of Cardiology, University Heart Center Zurich, Zurich, Switzerland
⨯
Matthias P. Nägele,

Roles Writing – review & editing

Affiliation Heart Failure and Heart Transplantation Unit, Department of Cardiology, University Heart Center Zurich, Zurich, Switzerland
⨯
Jens Barthelmes,

Roles Investigation, Writing – review & editing

Affiliation Heart Failure and Heart Transplantation Unit, Department of Cardiology, University Heart Center Zurich, Zurich, Switzerland
⨯
Frank Ruschitzka,

Roles Conceptualization, Resources, Supervision, Writing – review & editing

Affiliations Heart Failure and Heart Transplantation Unit, Department of Cardiology, University Heart Center Zurich, Zurich, Switzerland, Center for Translational and Experimental Cardiology, University Heart Center Zurich, Schlieren, Switzerland, University of Zurich, Zurich, Switzerland
⨯
Isabella Sudano,

Roles Resources, Supervision, Writing – review & editing

Affiliations Heart Failure and Heart Transplantation Unit, Department of Cardiology, University Heart Center Zurich, Zurich, Switzerland, Center for Translational and Experimental Cardiology, University Heart Center Zurich, Schlieren, Switzerland, University of Zurich, Zurich, Switzerland
⨯
Andreas J. Flammer

Roles Conceptualization, Methodology, Resources, Supervision, Validation, Writing – review & editing

Affiliations Heart Failure and Heart Transplantation Unit, Department of Cardiology, University Heart Center Zurich, Zurich, Switzerland, Center for Translational and Experimental Cardiology, University Heart Center Zurich, Schlieren, Switzerland, University of Zurich, Zurich, Switzerland
⨯

Effects of dapagliflozin on blood volume status and vascular outcomes in clinically stabilized heart failure patients after an acute decompensated heart failure event (DAPA-VOLVO study): Protocol of a double-blind randomized controlled clinical trial

Konstantinos Bitos,
Natallia Laptseva,
Thomas Haider,
Valentina A. Rossi,
Matthias P. Nägele,
Jens Barthelmes,
Frank Ruschitzka,
Isabella Sudano,
Andreas J. Flammer

Published: July 2, 2025
https://doi.org/10.1371/journal.pone.0325668

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