The association between labor epidural analgesia and early-onset postpartum hypertension among parturients with hypertensive disorders of pregnancy: A retrospective cohort study

Yongle Li; Jiteng Hu; Jiao Duan; Junjian Wen; Jianxiong Huang; Jie Shen; Zurong Hu; Zaisheng Qin

doi:10.1371/journal.pone.0325476

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Open Access

Peer-reviewed

Research Article

The association between labor epidural analgesia and early-onset postpartum hypertension among parturients with hypertensive disorders of pregnancy: A retrospective cohort study

Yongle Li ,

Contributed equally to this work with: Yongle Li, Jiteng Hu

Roles Formal analysis, Methodology, Writing – original draft

Affiliations Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China, Department of Anesthesiology, Guangzhou United Family Hospital, Guangzhou, Guangdong, China
⨯
Jiteng Hu ,

Contributed equally to this work with: Yongle Li, Jiteng Hu

Roles Formal analysis, Methodology, Writing – original draft

Affiliation State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
⨯
Jiao Duan,

Roles Data curation, Investigation, Validation

Affiliation Department of Anesthesiology, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Junjian Wen,

Roles Data curation, Investigation, Validation

Affiliation Department of Anesthesiology, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Jianxiong Huang,

Roles Data curation, Investigation, Software, Validation

Affiliation Department of Anesthesiology, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Jie Shen,

Roles Data curation, Investigation, Validation

Affiliation Department of Anesthesiology, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Zurong Hu ,

Roles Conceptualization, Funding acquisition, Supervision

* E-mail: mzkqzs@smu.edu.cn (ZQ); zurong.hu@hotmail.com (ZH)

Affiliation Department of Anesthesiology, Guangdong Women and Children Hospital, Guangzhou, Guangdong, China
⨯
Zaisheng Qin

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: mzkqzs@smu.edu.cn (ZQ); zurong.hu@hotmail.com (ZH)

Affiliation Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China

https://orcid.org/0000-0001-7798-1423

⨯

The association between labor epidural analgesia and early-onset postpartum hypertension among parturients with hypertensive disorders of pregnancy: A retrospective cohort study

Yongle Li,
Jiteng Hu,
Jiao Duan,
Junjian Wen,
Jianxiong Huang,
Jie Shen,
Zurong Hu,
Zaisheng Qin

Published: August 18, 2025
https://doi.org/10.1371/journal.pone.0325476

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Antihypertensives
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Hypertensive disorders in pregnancy
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Blood pressure
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Epidural block
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Antihypertensive drug therapy
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Cardiovascular disease risk
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Hypertension
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Obesity
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