Pluchea dioscoridis extract: A novel therapeutic approach for polycystic ovary syndrome targeting ovarian morphology, dopamine pathways, and neurobehavior in relation to its phytocomponents

• Rasha Atta ,

  Contributed equally to this work with: Rasha Atta, Sahar Galal Gouda, Marwa Hussein Mohamed, Abdelsamed I. Elshamy, Shimaa Mohammad Yousof

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: rasha_atta@med.suez.edu.eg

  Affiliations Medical Physiology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt, Center of Excellence in Molecular and Cellular Medicine (CEMCM), Faculty of Medicine, Suez Canal University, Ismailia, Egypt

  https://orcid.org/0000-0003-1547-1588

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• Sahar Galal Gouda ,

  Contributed equally to this work with: Rasha Atta, Sahar Galal Gouda, Marwa Hussein Mohamed, Abdelsamed I. Elshamy, Shimaa Mohammad Yousof

  Roles Investigation, Methodology, Software, Writing – original draft

  Affiliation Department of Histology and Cell Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

  ⨯
• Marwa Hussein Mohamed ,

  Contributed equally to this work with: Rasha Atta, Sahar Galal Gouda, Marwa Hussein Mohamed, Abdelsamed I. Elshamy, Shimaa Mohammad Yousof

  Roles Investigation, Methodology, Software, Writing – original draft

  Affiliation Department of Biochemistry and Molecular Biology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt

  ⨯
• Sherif M. Afifi ,

  Roles Investigation, Methodology, Software, Writing – original draft

  ¶‡ SMA, MIN, MAF, MAZ and TA also contributed equally to this work.

  Affiliation Department for Life Quality Studies, Rimini Campus, University of Bologna, Rimini, Italy

  ⨯
• Mahmoud I. Nassar ,

  Roles Investigation, Methodology, Software, Writing – original draft

  ¶‡ SMA, MIN, MAF, MAZ and TA also contributed equally to this work.

  Affiliation Department of Natural Compounds Chemistry, National Research Centre, Giza, Egypt

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• Mohamed A. Farag ,

  Roles Conceptualization, Visualization, Writing – review & editing

  ¶‡ SMA, MIN, MAF, MAZ and TA also contributed equally to this work.

  Affiliation Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

  ⨯
• Abdelsamed I. Elshamy ,

  Contributed equally to this work with: Rasha Atta, Sahar Galal Gouda, Marwa Hussein Mohamed, Abdelsamed I. Elshamy, Shimaa Mohammad Yousof

  Roles Investigation, Methodology, Software, Supervision, Writing – original draft, Writing – review & editing

  Affiliation Department of Natural Compounds Chemistry, National Research Centre, Giza, Egypt

  https://orcid.org/0000-0003-3302-3623

  ⨯
• Mohamed A. Zayed ,

  Roles Writing – original draft

  ¶‡ SMA, MIN, MAF, MAZ and TA also contributed equally to this work.

  Affiliations Medical Physiology, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia, Medical Physiology Department, Faculty of Medicine, Menoufia University, Shibin Al Kawm, Egypt, Neuroscience and Geroscience Unit, King Fahad Medical Research Centre, King Abdulaziz University, Jeddah, Saudi Arabia

  https://orcid.org/0000-0001-7064-183X

  ⨯
• Thamer Alqurashi ,

  Roles Funding acquisition

  ¶‡ SMA, MIN, MAF, MAZ and TA also contributed equally to this work.

  Affiliation Faculty of Medicine in Rabigh, Pharmacology Department, King Abdulaziz University, Jeddah, Saudi Arabia

  ⨯
• Shimaa Mohammad Yousof

  Contributed equally to this work with: Rasha Atta, Sahar Galal Gouda, Marwa Hussein Mohamed, Abdelsamed I. Elshamy, Shimaa Mohammad Yousof

  Roles Conceptualization, Funding acquisition, Software, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Medical Physiology Department, Faculty of Medicine, Suez Canal University, Ismailia, Egypt, Medical Physiology, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia, Neuroscience and Geroscience Unit, King Fahad Medical Research Centre, King Abdulaziz University, Jeddah, Saudi Arabia

  https://orcid.org/0000-0002-5996-8919

  ⨯