Ribitol treatment rescues dystroglycanopathy mice with common L276I mutation

Bo Wu; Pei Juan Lu; Morgan Drains; Sapana Shah; Anthony Blaeser; Victoria Leroy; Jessalyn Killilee; Molly Holbrook; Qi Long Lu

doi:10.1371/journal.pone.0325239

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Open Access

Peer-reviewed

Research Article

Ribitol treatment rescues dystroglycanopathy mice with common L276I mutation

Bo Wu,

Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation, Visualization, Writing – review & editing

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Pei Juan Lu,

Roles Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Morgan Drains,

Roles Data curation, Investigation, Methodology, Writing – review & editing

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Sapana Shah,

Roles Investigation, Methodology, Visualization

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Anthony Blaeser,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Victoria Leroy,

Roles Data curation, Investigation, Methodology

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Jessalyn Killilee,

Roles Investigation, Methodology, Visualization

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Molly Holbrook,

Roles Data curation, Investigation, Methodology, Visualization, Writing – review & editing

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America
⨯
Qi Long Lu

Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: qi.lu@atriumhealth.org

Affiliation McColl-Lockwood Laboratory for Muscular Dystrophy Research, Atrium Health Musculoskeletal Institute, Carolinas Medical Center, Charlotte, North Carolina, United States of America

https://orcid.org/0000-0002-6969-0121

⨯

Ribitol treatment rescues dystroglycanopathy mice with common L276I mutation

Bo Wu,
Pei Juan Lu,
Morgan Drains,
Sapana Shah,
Anthony Blaeser,
Victoria Leroy,
Jessalyn Killilee,
Molly Holbrook,
Qi Long Lu

Published: August 20, 2025
https://doi.org/10.1371/journal.pone.0325239

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