PPARγ inhibitors enhance the efficacy of statin therapy for steroid-induced osteonecrosis of the femoral head by directly inhibiting apoptosis and indirectly modulating lipoprotein subfractions

• Kai-yun Chen,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Writing – original draft

  Affiliations Department of Orthopedic Surgery, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China, Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

  https://orcid.org/0009-0009-9920-5340

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• Xu-huan Li,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology

  Affiliation Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

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• Dan Chen,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, First Affiliated Hospital of Hengyang Medical School, University of South China, Hengyang, Hunan, China

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• Shi-da Qian,

  Roles Formal analysis, Investigation, Methodology, Project administration

  Affiliation Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

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• Run-hong Mei,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China, Jiangxi Provincial Key Laboratory of Oral Diseases, Department of Stomatology, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

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• Qian Li,

  Roles Formal analysis, Investigation, Project administration, Resources

  Affiliation Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

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• Xue-feng Yu,

  Roles Formal analysis, Investigation

  Affiliation Affiliated Rehabilitation Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, China

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• Xi-jing He

  Roles Funding acquisition, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: ndsfy01067@ncu.edu.com

  Affiliations Department of Orthopedic Surgery, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China, Orthopedic Hospital, Xi’an International Medical Center Hospital, Xi’an, Shaanxi Province, China

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