Remote early detection of SARS-CoV-2 infections using a wearable-based algorithm: Results from the COVID-RED study, a prospective randomised single-blinded crossover trial

• Laura C. Zwiers ,

  Contributed equally to this work with: Laura C. Zwiers, Timo B. Brakenhoff

  Roles Writing – original draft, Writing – review & editing

  * E-mail: laura.zwiers@juliusclinical.com

  Affiliations Julius Clinical, Zeist, The Netherlands, Department of Global Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

  https://orcid.org/0009-0000-4080-6541

  ⨯
• Timo B. Brakenhoff ,

  Contributed equally to this work with: Laura C. Zwiers, Timo B. Brakenhoff

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Julius Clinical, Zeist, The Netherlands

  https://orcid.org/0000-0003-3543-6296

  ⨯
• Brianna M. Goodale,

  Roles Data curation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliations Julius Clinical, Zeist, The Netherlands, Ava AG, Zürich, Switzerland

  ⨯
• Duco Veen,

  Roles Formal analysis, Methodology, Writing – original draft, Writing – review & editing

  Affiliations Department of Methodology and Statistics, Utrecht University, Utrecht, The Netherlands, Optentia Research Programme, North-West University, Potchefstroom, South Africa

  https://orcid.org/0000-0002-8352-7574

  ⨯
• George S. Downward,

  Roles Project administration, Writing – original draft, Writing – review & editing

  Affiliations Department of Global Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands, Department of Environmental Epidemiology, Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, The Netherlands

  ⨯
• Vladimir Kovacevic,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliations Ava AG, Zürich, Switzerland, The Institute for Artificial Intelligence Research and Development of Serbia, Novi Sad, Serbia

  https://orcid.org/0000-0002-9843-6261

  ⨯
• Andjela Markovic,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliations Ava AG, Zürich, Switzerland, Department of Psychology, University of Fribourg, Fribourg, Switzerland

  https://orcid.org/0000-0003-2104-9543

  ⨯
• Marianna Mitratza,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Global Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

  ⨯
• Marcel van Willigen,

  Roles Data curation, Writing – review & editing

  Affiliation Julius Clinical, Zeist, The Netherlands

  https://orcid.org/0000-0003-3510-7564

  ⨯
• Billy Franks,

  Roles Conceptualization, Writing – review & editing

  Affiliation Julius Clinical, Zeist, The Netherlands

  https://orcid.org/0000-0002-1137-8792

  ⨯
• Janneke van de Wijgert,

  Roles Methodology, Writing – review & editing

  Affiliation Department of Epidemiology and Health Economics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

  https://orcid.org/0000-0003-2728-4560

  ⨯
• Santiago Montes,

  Roles Writing – review & editing

  Affiliation Roche Diagnostics Nederland B.V., Almere, The Netherlands

  ⨯
• Serkan Korkmaz,

  Roles Data curation, Writing – review & editing

  Affiliation VIVE, Copenhagen, Denmark

  https://orcid.org/0000-0002-5052-0982

  ⨯
• Jakob Kjellberg,

  Roles Data curation, Writing – review & editing

  Affiliation VIVE, Copenhagen, Denmark

  ⨯
• Lorenz Risch,

  Roles Conceptualization, Data curation, Project administration, Writing – review & editing

  Affiliations Laboratory Dr. Risch, Vaduz, Liechtenstein, Faculty of Medical Sciences, Insitute of Laboratory Medicine (ILM), Private University in the Principality of Liechtenstein (UFL), Triesen, Principality of Liechtenstein, Center of Laboratory Medicine, University Institute of Clinical Chemistry, University of Bern, Bern, Switzerland

  ⨯
• David Conen,

  Roles Conceptualization, Project administration, Writing – review & editing

  Affiliation Population Health Research Institute, McMaster University, Hamilton, Canada

  https://orcid.org/0000-0002-2459-5251

  ⨯
• Martin Risch,

  Roles Conceptualization, Data curation, Project administration, Writing – review & editing

  Affiliations Laboratory Dr. Risch, Vaduz, Liechtenstein, Central Laboratory, Kantonsspital Graubünden, Chur, Switzerland

  ⨯
• Kirsten Grossman,

  Roles Data curation, Formal analysis, Project administration, Writing – review & editing

  Affiliations Laboratory Dr. Risch, Vaduz, Liechtenstein, Faculty of Medical Sciences, Insitute of Laboratory Medicine (ILM), Private University in the Principality of Liechtenstein (UFL), Triesen, Principality of Liechtenstein

  https://orcid.org/0000-0002-0460-3736

  ⨯
• Ornella C. Weideli,

  Roles Project administration, Writing – review & editing

  Affiliations Laboratory Dr. Risch, Vaduz, Liechtenstein, Faculty of Medical Sciences, Insitute of Laboratory Medicine (ILM), Private University in the Principality of Liechtenstein (UFL), Triesen, Principality of Liechtenstein

  ⨯
• Theo Rispens,

  Roles Data curation, Resources, Writing – review & editing

  Affiliations Sanquin Research and Landsteiner Laboratory, Amsterdam UMC, Amsterdam, The Netherlands, Amsterdam Institute for Infection and Immunity, Amsterdam, The Netherlands

  ⨯
• Jon Bouwman,

  Roles Project administration, Writing – review & editing

  Affiliation Julius Clinical, Zeist, The Netherlands

  ⨯
• Amos A. Folarin,

  Roles Formal analysis, Writing – review & editing

  Affiliations Institute of Health Informatics, University College London, London, United Kingdom, NIHR Biomedical Research Centre, University College London Hospitals NHS Foundation Trust, London, United Kingdom, Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, United Kingdom

  ⨯
• Xi Bai,

  Roles Formal analysis, Writing – review & editing

  Affiliation Institute of Health Informatics, University College London, London, United Kingdom

  ⨯
• Richard Dobson,

  Roles Project administration, Writing – review & editing

  Affiliation Institute of Health Informatics, University College London, London, United Kingdom

  ⨯
• Maureen Cronin ,

  Roles Conceptualization, Data curation, Funding acquisition, Methodology, Writing – review & editing

  ¶‡ MC and DEG also contributed equally to this work.

  Affiliation Ava AG, Zürich, Switzerland

  ⨯
• Diederick E. Grobbee ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  ¶‡ MC and DEG also contributed equally to this work.

  Affiliations Julius Clinical, Zeist, The Netherlands, Department of Global Health and Bioethics, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

  ⨯
•  [ ... ],
• On behalf of the COVID-RED consortium

  ¶Membership of the COVID-RED consortium is provided in the Acknowledgements

  Affiliation Julius Clinical, Zeist, The Netherlands

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