Hypoxia regulates epithelial to mesenchymal transition-associated genes in human trophoblast cells by modulating DNA methylation

Jaganmoy Choudhury; Bodhana Dhole; Kanika Aggarwal; Palak Singh; Moses Azaraiah Jala; Deepak Pandey; Pradeep Kumar Chaturvedi; Surabhi Gupta

doi:10.1371/journal.pone.0325053

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Open Access

Peer-reviewed

Research Article

Hypoxia regulates epithelial to mesenchymal transition-associated genes in human trophoblast cells by modulating DNA methylation

Jaganmoy Choudhury,

Roles Conceptualization, Formal analysis, Methodology, Writing – original draft

Affiliation Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, INDIA
⨯
Bodhana Dhole,

Roles Formal analysis, Writing – review & editing

Affiliation Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, INDIA
⨯
Kanika Aggarwal,

Roles Investigation, Methodology

Affiliation Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, INDIA
⨯
Palak Singh,

Roles Investigation, Methodology

Affiliation Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, INDIA
⨯
Moses Azaraiah Jala,

Roles Investigation, Methodology

Affiliation Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, INDIA
⨯
Deepak Pandey,

Roles Supervision

Affiliation Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, INDIA
⨯
Pradeep Kumar Chaturvedi,

Roles Funding acquisition, Supervision

Affiliation Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, INDIA
⨯
Surabhi Gupta

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: surabhi@aiims.edu

Affiliation Department of Reproductive Biology, All India Institute of Medical Sciences, New Delhi, INDIA

https://orcid.org/0000-0001-6092-6575

⨯

Hypoxia regulates epithelial to mesenchymal transition-associated genes in human trophoblast cells by modulating DNA methylation

Jaganmoy Choudhury,
Bodhana Dhole,
Kanika Aggarwal,
Palak Singh,
Moses Azaraiah Jala,
Deepak Pandey,
Pradeep Kumar Chaturvedi,
Surabhi Gupta

Published: April 9, 2026
https://doi.org/10.1371/journal.pone.0325053

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DNA methylation
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Hypoxia
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Medical hypoxia
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Trophoblasts
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Gene expression
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Promoter regions
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Polymerase chain reaction
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Transcription factors
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