Correlation analysis of mitochondrial DNA maintenance-related genes with HCC prognosis, tumor mutation burden and tumor microenvironment features

Fan Rong; Bin Cheng; Ling Guo; Shaobo Zeng; Xunliang Xu; Zhongji Meng

doi:10.1371/journal.pone.0325033

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Open Access

Peer-reviewed

Research Article

Correlation analysis of mitochondrial DNA maintenance-related genes with HCC prognosis, tumor mutation burden and tumor microenvironment features

Fan Rong ,

Contributed equally to this work with: Fan Rong, Bin Cheng

Roles Data curation, Writing – original draft

Affiliation Department of Infectious Diseases, Institute of Biomedical Research, Regulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key Laboratory, Hubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, China
⨯
Bin Cheng ,

Contributed equally to this work with: Fan Rong, Bin Cheng

Roles Software, Writing – review & editing

Affiliation Department of Infectious Diseases, Institute of Biomedical Research, Regulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key Laboratory, Hubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, China
⨯
Ling Guo,

Roles Visualization, Writing – review & editing

Affiliation Department of Infectious Diseases, Institute of Biomedical Research, Regulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key Laboratory, Hubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, China
⨯
Shaobo Zeng,

Roles Visualization, Writing – review & editing

Affiliation Department of Hepatobiliary Pancreatic Surgery, Wudangshan Branch of Taihe Hospital, Hubei University of Medicine, Shiyan, China
⨯
Xunliang Xu,

Roles Visualization, Writing – review & editing

Affiliation Hubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, China
⨯
Zhongji Meng

Roles Supervision, Visualization, Writing – review & editing

* E-mail: zhongjimeng@163.com

Affiliation Department of Infectious Diseases, Institute of Biomedical Research, Regulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key Laboratory, Hubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver Cancer, Taihe Hospital, Hubei University of Medicine, Shiyan, China

https://orcid.org/0000-0003-0401-535X

⨯

Correlation analysis of mitochondrial DNA maintenance-related genes with HCC prognosis, tumor mutation burden and tumor microenvironment features

Fan Rong,
Bin Cheng,
Ling Guo,
Shaobo Zeng,
Xunliang Xu,
Zhongji Meng

Published: June 2, 2025
https://doi.org/10.1371/journal.pone.0325033

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Hepatocellular carcinoma
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