Protocol for EpiCom: A phase 3b/4 study of behavioral outcomes following adjunctive cannabidiol for the management of tuberous sclerosis complex-associated neuropsychiatric disorders (TAND)

Agnies M. van Eeghen; Elizabeth A. Thiele; Sam Amin; Debopam Samanta; Anna C. Jansen; Joanne Stevens; Lisa Moore-Ramdin; Petrus J. de Vries

doi:10.1371/journal.pone.0324648

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Protocol for EpiCom: A phase 3b/4 study of behavioral outcomes following adjunctive cannabidiol for the management of tuberous sclerosis complex-associated neuropsychiatric disorders (TAND)

Agnies M. van Eeghen,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliations Emma Center for Personalized Medicine, Emma Children’s Hospital, Amsterdam University Medical Centers, Amsterdam, Netherlands, Advisium, ‘s Heeren Loo, Amersfoort, Netherlands

https://orcid.org/0000-0001-8149-8645

⨯
Elizabeth A. Thiele,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Massachusetts General Hospital, Boston, Massachusetts, United States of America
⨯
Sam Amin,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Paediatric Neurology, University Hospitals Bristol and Weston, Bristol, United Kingdom
⨯
Debopam Samanta,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Child Neurology Section, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
⨯
Anna C. Jansen,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Department of Pediatrics, Pediatric Neurology Unit, Antwerp University Hospital, Edegem, Belgium

https://orcid.org/0000-0002-3835-2824

⨯
Joanne Stevens,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Jazz Pharmaceuticals, Inc., Philadelphia, Pennsylvania, United States of America
⨯
Lisa Moore-Ramdin ,

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

* E-mail: Lisa.Moore-Ramdin@jazzpharma.com

Affiliation Jazz Pharmaceuticals, Inc., London, United Kingdom

https://orcid.org/0009-0000-2499-1775

⨯
Petrus J. de Vries

Roles Conceptualization, Methodology, Supervision, Writing – review & editing

Affiliation Center for Autism Research in Africa, Division of Child & Adolescent Psychiatry, University of Cape Town, Cape Town, South Africa
⨯

Protocol for EpiCom: A phase 3b/4 study of behavioral outcomes following adjunctive cannabidiol for the management of tuberous sclerosis complex-associated neuropsychiatric disorders (TAND)

Agnies M. van Eeghen,
Elizabeth A. Thiele,
Sam Amin,
Debopam Samanta,
Anna C. Jansen,
Joanne Stevens,
Lisa Moore-Ramdin,
Petrus J. de Vries

Published: June 12, 2025
https://doi.org/10.1371/journal.pone.0324648

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