Transcriptomic response of skeletal muscle to acute aerobic versus combined exercise in chronic kidney disease

Luke A. Baker; Matthew Graham-Brown; Thomas J. Wilkinson; Alice C. Smith; Emma L. Watson

doi:10.1371/journal.pone.0324303

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Peer-reviewed

Research Article

Transcriptomic response of skeletal muscle to acute aerobic versus combined exercise in chronic kidney disease

Luke A. Baker ,

Contributed equally to this work with: Luke A. Baker, Emma L. Watson

Roles Data curation, Supervision, Writing – review & editing, Conceptualization

Affiliations Division of Respiratory Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom, Leicester Biomedical Research Centre, Leicester Diabetes Centre, University of Leicester, Leicester, United Kingdom

https://orcid.org/0000-0003-2111-3832

⨯
Matthew Graham-Brown ,

Roles Data curation, Writing – review & editing

¶‡ These authors contributed equally to this work.

Affiliation Division of Cardiovascular Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom
⨯
Thomas J. Wilkinson ,

Roles Writing – review & editing, Data curation

¶‡ These authors contributed equally to this work.

Affiliations Leicester Biomedical Research Centre, Leicester Diabetes Centre, University of Leicester, Leicester, United Kingdom, Division of Global Health, Lifestyle and Metabolic Health, Leicester, United Kingdom
⨯
Alice C. Smith ,

Roles Conceptualization, Data curation, Funding acquisition, Investigation, Writing – review & editing

¶‡ These authors contributed equally to this work.

Affiliation Division of Public Health and Epidemiology, School of Medical Sciences, University of Leicester, Leicester, United Kingdom
⨯
Emma L. Watson

Contributed equally to this work with: Luke A. Baker, Emma L. Watson

Roles Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing, Data curation

* E-mail: Emma.watson@leicester.ac.uk

Affiliations Leicester Biomedical Research Centre, Leicester Diabetes Centre, University of Leicester, Leicester, United Kingdom, Division of Cardiovascular Sciences, College of Life Sciences, University of Leicester, Leicester, United Kingdom

https://orcid.org/0000-0002-3869-8972

⨯

Transcriptomic response of skeletal muscle to acute aerobic versus combined exercise in chronic kidney disease

Luke A. Baker,
Matthew Graham-Brown,
Thomas J. Wilkinson,
Alice C. Smith,
Emma L. Watson

Published: February 25, 2026
https://doi.org/10.1371/journal.pone.0324303

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Skeletal muscles
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Exercise
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Mitochondria
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Inflammation
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Gene expression
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Chronic kidney disease
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Muscle regeneration
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Muscle proteins
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