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Open Access
Peer-reviewed
Research Article
Phenome-wide association study and functional annotation of hemoglobin A1c-associated variants in African populations
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Chisom Soremekun,
Roles Conceptualization, Formal analysis, Writing – original draft
Affiliations NCD Genomics & The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda, Department of Immunology and Molecular Biology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda, Centre for Genomics Research and Innovation, National Biotechnology Development Agency, Abuja, Nigeria, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Ingolstädter Landstr, Neuherberg, Germany
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Oyesola Ojewunmi,
Roles Writing – review & editing
Affiliations NCD Genomics & The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda, Precision Healthcare University Research Institute, Queen Mary University of London, United Kingdom
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Amarachukwu Nwagbata,
Roles Writing – review & editing
Affiliation Usher Institute, University of Edinburgh, Edinburgh, United Kingdom
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Homa Bazireh,
Roles Writing – review & editing
Affiliations Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Ingolstädter Landstr, Neuherberg, Germany, Faculty of Medicine, Ludwig-Maximilians-University München, München, Germany
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Sapna Sharma,
Roles Writing – review & editing
Affiliation Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Ingolstädter Landstr, Neuherberg, Germany
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Daudi Jjingo,
Roles Supervision
Affiliations African Center of Excellence in Bioinformatics and Data-Intensive Sciences, Infectious Diseases Institute, Kampala, Uganda, Department of Computer Science, Makerere University, Kampala, Uganda
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David Patrick Kateete,
Roles Supervision, Writing – review & editing
Affiliation Department of Immunology and Molecular Biology, School of Biomedical Sciences, Makerere University College of Health Sciences, Kampala, Uganda
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Oyekanmi Nash,
Roles Resources
Affiliation Centre for Genomics Research and Innovation, National Biotechnology Development Agency, Abuja, Nigeria
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Harald Grallert,
Roles Resources, Supervision
Affiliations Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Ingolstädter Landstr, Neuherberg, Germany, German Center for Diabetes Research (DZD), München-Neuherberg, Ingolstädter Landstr, Neuherberg, Germany
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Chiara Batini,
Roles Supervision, Writing – review & editing
Affiliations Department of Population Health Sciences, University of Leicester, Leicester, United Kingdom, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom
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Annette Peters,
Roles Resources
Affiliations Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Ingolstädter Landstr, Neuherberg, Germany, German Center for Diabetes Research (DZD), München-Neuherberg, Ingolstädter Landstr, Neuherberg, Germany, Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universität München, Munich, Germany
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Segun Fatumo
Roles Conceptualization, Supervision, Writing – review & editing
* E-mail: s.fatumo@qmul.ac.uk
Affiliations NCD Genomics & The African Computational Genomics (TACG) Research Group, MRC/UVRI and LSHTM Uganda Research Unit, Entebbe, Uganda, Precision Healthcare University Research Institute, Queen Mary University of London, United Kingdom
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Phenome-wide association study and functional annotation of hemoglobin A1c-associated variants in African populations
- Chisom Soremekun,
- Oyesola Ojewunmi,
- Amarachukwu Nwagbata,
- Homa Bazireh,
- Sapna Sharma,
- Daudi Jjingo,
- David Patrick Kateete,
- Oyekanmi Nash,
- Harald Grallert,
- Chiara Batini
- Published: May 30, 2025
- https://doi.org/10.1371/journal.pone.0324269