Disruption of adaptive immunity does not attenuate disease in the Ndufs4(-/-) model of Leigh syndrome

• Allison R. Hanaford,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America, Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

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• Asheema Khanna,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

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• Vivian Truong,

  Roles Investigation

  Affiliation Department of Applied Sciences, Translational Bioscience, Northumbria University, Newcastle, United Kingdom

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• Katerina James,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Applied Sciences, Translational Bioscience, Northumbria University, Newcastle, United Kingdom

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• Ryan Liao,

  Roles Investigation

  Affiliation Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

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• Yihan Chen,

  Roles Investigation

  Affiliation Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

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• Michael Mulholland,

  Roles Investigation

  Affiliation Department of Applied Sciences, Translational Bioscience, Northumbria University, Newcastle, United Kingdom

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• Ernst-Bernhard Kayser,

  Roles Investigation, Writing – review & editing

  Affiliation Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

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• Kino Watanabe,

  Roles Investigation

  Affiliation Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

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• Erin Shien Hsieh,

  Roles Investigation

  Affiliation Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America

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• Philip G. Morgan,

  Roles Project administration, Resources, Supervision

  Affiliations Center for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, Washington, United States of America

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• Surojit Sarkar,

  Roles Methodology, Supervision, Validation, Visualization

  Affiliations Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America, Department of Paediatrics, University of Washington School of Medicine, Seattle, Washington, United States of America

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• Vandana Kalia ,

  Roles Conceptualization, Formal analysis, Methodology, Project administration, Resources, Supervision

  ¶‡ Co-senior authors.

  Affiliations Ben Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children’s Research Institute, Seattle, Washington, United States of America, Department of Paediatrics, University of Washington School of Medicine, Seattle, Washington, United States of America

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• Simon C. Johnson

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

  * E-mail: simon.c.johnson@northumbria.ac.uk

  ¶‡ Co-senior authors.

  Affiliation Department of Applied Sciences, Translational Bioscience, Northumbria University, Newcastle, United Kingdom

  https://orcid.org/0000-0002-1942-3674

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