Human umbilical cord mesenchymal stem cell-derived exosomes mitigate acute radiation-induced intestinal oxidative damage via the Nrf2/HO-1/NQO1 signaling pathway

Hongyu Wang; Jinbao Wang; Gaosheng Yang; Yanjie Li; Weikai Chen; Jianping Yu; Xiaopeng Han

doi:10.1371/journal.pone.0324238

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Open Access

Peer-reviewed

Research Article

Human umbilical cord mesenchymal stem cell-derived exosomes mitigate acute radiation-induced intestinal oxidative damage via the Nrf2/HO-1/NQO1 signaling pathway

Hongyu Wang,

Roles Visualization, Writing – original draft

Affiliations The First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, China, Department of General Surgery I, Gansu Provincial Central Hospital, Lanzhou, China

https://orcid.org/0009-0004-9214-5000

⨯
Jinbao Wang,

Roles Formal analysis, Investigation

Affiliations The First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, China, Department of General Surgery I, Gansu Provincial Central Hospital, Lanzhou, China
⨯
Gaosheng Yang,

Roles Formal analysis, Investigation

Affiliations The First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, China, Department of General Surgery I, Gansu Provincial Central Hospital, Lanzhou, China
⨯
Yanjie Li,

Roles Formal analysis, Investigation

Affiliations The First School of Clinical Medicine, Gansu University of Chinese Medicine, Lanzhou, China, Department of General Surgery I, Gansu Provincial Central Hospital, Lanzhou, China
⨯
Weikai Chen,

Roles Conceptualization, Methodology

Affiliation Department of General Surgery I, Gansu Provincial Central Hospital, Lanzhou, China
⨯
Jianping Yu ,

Roles Funding acquisition, Writing – review & editing

* E-mail: hanxiaopeng74@163.com (XH); yujianpingld@163.com (JY)

Affiliation Department of General Surgery I, Gansu Provincial Central Hospital, Lanzhou, China
⨯
Xiaopeng Han

Roles Funding acquisition, Writing – review & editing

* E-mail: hanxiaopeng74@163.com (XH); yujianpingld@163.com (JY)

Affiliation Department of General Surgery I, Gansu Provincial Central Hospital, Lanzhou, China

https://orcid.org/0000-0002-7815-1779

⨯

Human umbilical cord mesenchymal stem cell-derived exosomes mitigate acute radiation-induced intestinal oxidative damage via the Nrf2/HO-1/NQO1 signaling pathway

Hongyu Wang,
Jinbao Wang,
Gaosheng Yang,
Yanjie Li,
Weikai Chen,
Jianping Yu,
Xiaopeng Han

Published: June 6, 2025
https://doi.org/10.1371/journal.pone.0324238

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