Identifying optimal combination regimens for therapy of Mycobacterium tuberculosis with an algorithmic approach: prospective predictions and validations

• Arnold Louie ,

  Contributed equally to this work with: Arnold Louie, Michael Neely, Sarah Kim, Charles A. Scanga, JoAnne L. Flynn, Charles A. Peloquin, Brendan Prideaux, Stephan Schmidt, Mohammed Almoslem, Walter Yamada, George Drusano

  Roles Investigation, Methodology, Project administration, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: Arnold.Louie@medicine.ufl.edu (AL); gdrusano@ufl.edu (GD)

  Affiliation Institute for Therapeutic Innovation, University of Florida College of Medicine Orlando, Florida, United States of America

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• Michael Neely ,

  Contributed equally to this work with: Arnold Louie, Michael Neely, Sarah Kim, Charles A. Scanga, JoAnne L. Flynn, Charles A. Peloquin, Brendan Prideaux, Stephan Schmidt, Mohammed Almoslem, Walter Yamada, George Drusano

  Roles Formal analysis, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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• Sarah Kim ,

  Contributed equally to this work with: Arnold Louie, Michael Neely, Sarah Kim, Charles A. Scanga, JoAnne L. Flynn, Charles A. Peloquin, Brendan Prideaux, Stephan Schmidt, Mohammed Almoslem, Walter Yamada, George Drusano

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations Institute for Therapeutic Innovation, University of Florida College of Medicine Orlando, Florida, United States of America, Department of Pharmaceutics, Center for Pharmacometrics and System Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, United States of America]

  https://orcid.org/0000-0002-9179-0735

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• Charles A. Scanga ,

  Contributed equally to this work with: Arnold Louie, Michael Neely, Sarah Kim, Charles A. Scanga, JoAnne L. Flynn, Charles A. Peloquin, Brendan Prideaux, Stephan Schmidt, Mohammed Almoslem, Walter Yamada, George Drusano

  Roles Data curation, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Molecular Genetics and Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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• JoAnne L. Flynn ,

  Contributed equally to this work with: Arnold Louie, Michael Neely, Sarah Kim, Charles A. Scanga, JoAnne L. Flynn, Charles A. Peloquin, Brendan Prideaux, Stephan Schmidt, Mohammed Almoslem, Walter Yamada, George Drusano

  Roles Data curation, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology and Molecular Genetics and Center for Vaccine Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America

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• Charles A. Peloquin ,

  Contributed equally to this work with: Arnold Louie, Michael Neely, Sarah Kim, Charles A. Scanga, JoAnne L. Flynn, Charles A. Peloquin, Brendan Prideaux, Stephan Schmidt, Mohammed Almoslem, Walter Yamada, George Drusano

  Roles Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation Pharmacotherapy & Translational Research, University of Florida College of Pharmacy, Gainesville, Florida, United States of America

  https://orcid.org/0000-0001-9002-7052

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• Brendan Prideaux ,

  Contributed equally to this work with: Arnold Louie, Michael Neely, Sarah Kim, Charles A. Scanga, JoAnne L. Flynn, Charles A. Peloquin, Brendan Prideaux, Stephan Schmidt, Mohammed Almoslem, Walter Yamada, George Drusano

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Neurobiology, The University of Texas Medical Branch Galveston, Galveston, Texas, United States of America

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• Stephan Schmidt ,

  Contributed equally to this work with: Arnold Louie, Michael Neely, Sarah Kim, Charles A. Scanga, JoAnne L. Flynn, Charles A. Peloquin, Brendan Prideaux, Stephan Schmidt, Mohammed Almoslem, Walter Yamada, George Drusano

  Roles Data curation, Validation, Writing – review & editing

  Affiliation Department of Pharmaceutics, Center for Pharmacometrics and System Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, United States of America]

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• Mohammed Almoslem ,

  Contributed equally to this work with: Arnold Louie, Michael Neely, Sarah Kim, Charles A. Scanga, JoAnne L. Flynn, Charles A. Peloquin, Brendan Prideaux, Stephan Schmidt, Mohammed Almoslem, Walter Yamada, George Drusano

  Roles Validation, Writing – review & editing, Data curation

  Affiliations Department of Pharmaceutics, Center for Pharmacometrics and System Pharmacology, College of Pharmacy, University of Florida, Orlando, Florida, United States of America], Department of Clinical Pharmacy, University of Ha'il, Ha'il, Kingdom of Saudi Arabia

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• Walter Yamada ,

  Contributed equally to this work with: Arnold Louie, Michael Neely, Sarah Kim, Charles A. Scanga, JoAnne L. Flynn, Charles A. Peloquin, Brendan Prideaux, Stephan Schmidt, Mohammed Almoslem, Walter Yamada, George Drusano

  Roles Formal analysis, Methodology, Software, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Applied Pharmacokinetics and Bioinformatics, The Saban Research Institute, Children's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

  https://orcid.org/0000-0003-3512-9202

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• George Drusano

  Contributed equally to this work with: Arnold Louie, Michael Neely, Sarah Kim, Charles A. Scanga, JoAnne L. Flynn, Charles A. Peloquin, Brendan Prideaux, Stephan Schmidt, Mohammed Almoslem, Walter Yamada, George Drusano

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: Arnold.Louie@medicine.ufl.edu (AL); gdrusano@ufl.edu (GD)

  ¶Deceased.

  Affiliation Institute for Therapeutic Innovation, University of Florida College of Medicine Orlando, Florida, United States of America

  https://orcid.org/0000-0001-9162-7332

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