Engineering of long-acting human growth hormone-Fc fusion proteins: Effects of valency, fusion position, and linker design on pharmacokinetics and efficacy

• Taekyeol Lee ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: leety@donga.co.kr

  Affiliations Biologics Research Laboratories of R&D center, Dong-A Socio Holdings, Yong-In, Korea, Department of Life Science, Sogang University, Seoul, Korea

  https://orcid.org/0009-0009-7950-313X

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• Dongsop Lee,

  Roles Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft

  Affiliation Biologics Research Laboratories of R&D center, Dong-A Socio Holdings, Yong-In, Korea

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• Eunee Jung,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Biologics Research Laboratories of R&D center, Dong-A Socio Holdings, Yong-In, Korea

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• Mikyung Son,

  Roles Data curation, Formal analysis, Investigation, Methodology, Supervision, Validation

  Affiliation Biologics Research Laboratories of R&D center, Dong-A Socio Holdings, Yong-In, Korea

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• Kyohwan Koo,

  Roles Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Biologics Research Laboratories of R&D center, Dong-A Socio Holdings, Yong-In, Korea

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• Jaehoon Choi

  Roles Conceptualization, Project administration, Validation, Writing – review & editing

  Affiliation Biologics Research Laboratories of R&D center, Dong-A Socio Holdings, Yong-In, Korea

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