Impact of statins as immune-modulatory agents on inflammatory markers in adults with chronic diseases: A systematic review and meta-analysis

• Solima Sabeel ,

  Contributed equally to this work with: Solima Sabeel, Bongani Motaung, Kim A. Nguyen

  Roles Conceptualization, Data curation, Writing – original draft

  Affiliations Institute of Infectious Diseases and Molecular Medicine (IDM), Department of Pathology, Division of Immunology, Faculty of Health Sciences, University of Cape Town, South Africa, International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa

  https://orcid.org/0000-0003-4200-8994

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• Bongani Motaung ,

  Contributed equally to this work with: Solima Sabeel, Bongani Motaung, Kim A. Nguyen

  Roles Conceptualization, Data curation, Writing – original draft

  Affiliations Institute of Infectious Diseases and Molecular Medicine (IDM), Department of Pathology, Division of Immunology, Faculty of Health Sciences, University of Cape Town, South Africa, International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa

  https://orcid.org/0000-0002-4416-8353

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• Kim A. Nguyen ,

  Contributed equally to this work with: Solima Sabeel, Bongani Motaung, Kim A. Nguyen

  Roles Data curation, Formal analysis

  Affiliation Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa

  https://orcid.org/0000-0001-9650-4796

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• Mumin Ozturk,

  Roles Conceptualization, Writing – review & editing

  Affiliations Institute of Infectious Diseases and Molecular Medicine (IDM), Department of Pathology, Division of Immunology, Faculty of Health Sciences, University of Cape Town, South Africa, International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa

  https://orcid.org/0000-0001-9152-7614

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• Sandra L. Mukasa,

  Roles Writing – review & editing

  Affiliation General Medicine & Global Health (GMGH), Department of Medicine and Cape Heart Institute, Faculty of Health Science, University of Cape Town, South Africa

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• Karen Wolmarans,

  Roles Writing – review & editing

  Affiliation General Medicine & Global Health (GMGH), Department of Medicine and Cape Heart Institute, Faculty of Health Science, University of Cape Town, South Africa

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• Dirk J. Blom,

  Roles Writing – review & editing

  Affiliation Division of Lipidology, Department of Medicine and Cape Heart Institute, University of Cape Town, South Africa

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• Karen Sliwa,

  Roles Writing – review & editing

  Affiliation Cape Heart Institute and Division of Cardiology, Department of Medicine, Faculty of Health Sciences, University of Cape Town, South Africa

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• Emmanuel Nepolo,

  Roles Writing – review & editing

  Affiliation Department of Human, Biological & Translational Sciences, School of Medicine, University of Namibia, Windhoek, Namibia

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• Gunar Günther,

  Roles Writing – review & editing

  Affiliations Department of Human, Biological & Translational Sciences, School of Medicine, University of Namibia, Windhoek, Namibia, Department of Pulmonary Medicine and Allergology, Inselspital, Bern University Hospital, University of Bern, Switzerland

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• Robert J. Wilkinson,

  Roles Writing – review & editing

  Affiliations Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, South Africa, Francis Crick Institute, London, United Kingdom, Department of Infectious Diseases, Imperial College London, United Kingdom

  https://orcid.org/0000-0002-2753-1800

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• Claudia Schacht,

  Roles Writing – review & editing

  Affiliation Linq management GmbH, Berlin, Germany

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• Andre Pascal Kengne,

  Roles Formal analysis

  Affiliations Non-Communicable Diseases Research Unit, South African Medical Research Council, Cape Town, South Africa, Department of Medicine, University of Cape Town, Cape Town, South Africa

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• Friedrich Thienemann ,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: reto.guler@uct.ac.za (RG); friedrich.thienemann@uct.ac.za (FT)

  ¶‡ FT and RG also contributed equally to this work.

  Affiliations General Medicine & Global Health (GMGH), Department of Medicine and Cape Heart Institute, Faculty of Health Science, University of Cape Town, South Africa, Department of Internal Medicine, University Hospital Zurich, University of Zurich, Switzerland, Cape Universities Body Imaging Centre (CUBIC), University of Cape Town, South Africa

  https://orcid.org/0000-0002-4801-2030

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• Reto Guler

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  * E-mail: reto.guler@uct.ac.za (RG); friedrich.thienemann@uct.ac.za (FT)

  ¶‡ FT and RG also contributed equally to this work.

  Affiliations Institute of Infectious Diseases and Molecular Medicine (IDM), Department of Pathology, Division of Immunology, Faculty of Health Sciences, University of Cape Town, South Africa, International Centre for Genetic Engineering and Biotechnology (ICGEB), Cape Town Component, Cape Town, South Africa, Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine (IDM), Faculty of Health Sciences, University of Cape Town, South Africa

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