Design, synthesis and in silico molecular modelling studies of 2-Hydrazineyl-2-oxoethyl-4-(1H-pyrrol-1-yb) benzoate derivatives: a potent dual DHFR and ENR-reductase inhibitors with antitubercular, antibacterial and cytotoxic potential

• Mater H. Mahnashi,

  Roles Funding acquisition, Project administration, Writing – review & editing

  Affiliation Department of Pharmaceutical Chemistry, College of Pharmacy, King Khalid University, Abha, Saudi Arabia

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• Prem Kumar Santhemavathuru Ramachandraiah,

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft

  Affiliation Department of Pharmaceutical Quality Assurance, Sree Siddaganga College of Pharmacy, Tumkur, Karnataka, India

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• Ahmed Abdullah Al Awadh,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran, Saudi Arabia

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• Ibrahim Abdullah Almazni,

  Roles Formal analysis, Resources, Writing – review & editing

  Affiliation Department of Clinical Laboratory Sciences, Faculty of Applied Medical Sciences, Najran University, Najran, Saudi Arabia

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• Yahya I. Asiri,

  Roles Formal analysis, Software, Writing – review & editing

  Affiliation Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia

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• Ibrahim Ahmed Shaikh,

  Roles Conceptualization, Investigation, Software, Writing – review & editing

  Affiliation Department of Pharmacology, College of Pharmacy, Najran University, Najran, Saudi Arabia

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• Basheerahmed Abdulaziz Mannasaheb,

  Roles Formal analysis, Software, Writing – review & editing

  Affiliation Department of Pharmacy Practice, College of Pharmacy, AlMaarefa University, Riyadh, Saudi Arabia

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• Sravanthi Avunoori,

  Roles Conceptualization, Investigation, Methodology, Writing – original draft

  Affiliation Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry, SET’s College of Pharmacy, Dharwad, Karnataka, India

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• Aejaz Abdullatif Khan,

  Roles Methodology, Software, Writing – review & editing

  Affiliation Department of General Science, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia

  https://orcid.org/0000-0002-5731-7522

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• Shrinivas D. Joshi

  Roles Conceptualization, Data curation, Project administration, Writing – original draft

  * E-mail: shrinivasdj@rediffmail.com

  Affiliation Novel Drug Design and Discovery Laboratory, Department of Pharmaceutical Chemistry, SET’s College of Pharmacy, Dharwad, Karnataka, India

  https://orcid.org/0000-0002-6520-806X

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