Klotho null mutation leads to retinal degeneration characterized by functional impairment, gliosis, and deposition of amyloid-beta and hyperphosphorylated tau proteins

• Zhi-Jia Chen,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft

  Affiliation Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, TaiwanRepublic of China

  https://orcid.org/0009-0005-2317-5668

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• Chun-Yen Wu,

  Roles Formal analysis, Investigation, Methodology, Project administration, Visualization

  Affiliation Department of Nutrition, Chung Shan Medical University, Taichung, TaiwanRepublic of China

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• Fang-Yan Hsiao,

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliation Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, TaiwanRepublic of China

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• Jing-Chun Ma,

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliation Department of Nutrition, Chung Shan Medical University, Taichung, TaiwanRepublic of China

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• Gabriel Lai,

  Roles Formal analysis, Investigation, Methodology, Visualization

  Affiliation Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, TaiwanRepublic of China

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• Han-Hsin Chang,

  Roles Conceptualization, Funding acquisition, Resources, Validation, Writing – review & editing

  Affiliation Department of Nutrition, Chung Shan Medical University, Taichung, TaiwanRepublic of China

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• David Pei-Cheng Lin

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Validation, Writing – review & editing

  * E-mail: pcl@csmu.edu.tw

  Affiliations Department of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, TaiwanRepublic of China, Department of Ophthalmology, Chung Shan Medical University Hospital, Taichung, TaiwanRepublic of China.

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