Minocycline inhibits rosacea-like inflammation through the TLR4-mediated NF-κB signaling pathway in vivo and in vitro

Piyan Hua; Ying Tu; Zhenghui Yang; Yunting He; Li He; Qiuyan Yao; Hua Gu

doi:10.1371/journal.pone.0323598

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Open Access

Peer-reviewed

Research Article

Minocycline inhibits rosacea-like inflammation through the TLR4-mediated NF-κB signaling pathway in vivo and in vitro

Piyan Hua ,

Contributed equally to this work with: Piyan Hua, Ying Tu

Roles Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
⨯
Ying Tu ,

Contributed equally to this work with: Piyan Hua, Ying Tu

Roles Data curation, Supervision, Visualization

Affiliation Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
⨯
Zhenghui Yang,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
⨯
Yunting He,

Roles Formal analysis, Investigation, Methodology, Validation

Affiliation Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
⨯
Li He,

Roles Supervision

Affiliation Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
⨯
Qiuyan Yao,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China
⨯
Hua Gu

Roles Conceptualization, Data curation, Funding acquisition, Writing – review & editing

* E-mail: guhua1978@sina.com

Affiliation Department of Dermatology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China

https://orcid.org/0000-0002-6207-5337

⨯

Minocycline inhibits rosacea-like inflammation through the TLR4-mediated NF-κB signaling pathway in vivo and in vitro

Piyan Hua,
Ying Tu,
Zhenghui Yang,
Yunting He,
Li He,
Qiuyan Yao,
Hua Gu

Published: May 16, 2025
https://doi.org/10.1371/journal.pone.0323598

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Transcription factors
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