Effects of combination therapy of a CDK4/6 and MEK inhibitor in diffuse midline glioma preclinical models

• Yusuke Tomita,

  Roles Data curation, Formal analysis, Investigation, Writing – original draft

  Affiliations Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Department of Neurosurgery and Neuroendovascular Surgery, Hiroshima City Hiroshima Citizens Hospital, Hiroshima, Japan

  https://orcid.org/0000-0002-3964-823X

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• Gabrielle Link,

  Roles Investigation

  Affiliation Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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• Yi Ge,

  Roles Data curation, Investigation

  Affiliations The Jack Martin Fund Division of Pediatric Hematology-Oncology, Mount Sinai Kravis Children’s Hospital, New York, New York, United States of America, Department of Oncological Sciences, Mount Sinai Health System, New York, New York, United States of America

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• Emma R. H. Gold,

  Roles Writing – review & editing

  Affiliations The Jack Martin Fund Division of Pediatric Hematology-Oncology, Mount Sinai Kravis Children’s Hospital, New York, New York, United States of America, Department of Oncological Sciences, Mount Sinai Health System, New York, New York, United States of America

  https://orcid.org/0009-0001-5667-8553

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• Anna Racanelli,

  Roles Methodology

  Affiliations The Jack Martin Fund Division of Pediatric Hematology-Oncology, Mount Sinai Kravis Children’s Hospital, New York, New York, United States of America, Department of Oncological Sciences, Mount Sinai Health System, New York, New York, United States of America

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• Herminio Joey Cardona,

  Roles Investigation, Resources

  Affiliation Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

  ⨯
• Megan Romero,

  Roles Investigation, Resources

  Affiliation Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

  ⨯
• Samantha Gadd,

  Roles Formal analysis, Investigation, Visualization

  Affiliation Department of Pathology, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, United States of America

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• Jun Watanabe,

  Roles Data curation, Investigation

  Affiliation Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Eita Uchida,

  Roles Investigation

  Affiliation Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

  https://orcid.org/0000-0002-3056-5446

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• Rintaro Hashizume,

  Roles Data curation, Investigation

  Affiliations Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Division of Hematology-Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, United States of America, Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, Division of Pediatric Hematology-Oncology, Children’s of Alabama, Birmingham, Alabama, United States of America, O’Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, United States of America

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• Nozomu Takata,

  Roles Investigation

  Affiliations Center for Vascular and Developmental Biology, Feinberg Cardiovascular and Renal Research Institute, Northwestern University, Chicago, Illinois, United States of America, Simpson Querrey Institute for BioNanotechnology, Northwestern University, Chicago, Illinois, United States of America

  https://orcid.org/0000-0003-0171-6994

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• Gonzalo Pinero,

  Roles Investigation

  Affiliations Department of Oncological Sciences, Mount Sinai Health System, New York, New York, United States of America, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, United States of America

  ⨯
• Dolores Hambardzumyan,

  Roles Investigation

  Affiliations Department of Oncological Sciences, Mount Sinai Health System, New York, New York, United States of America, Department of Neurosurgery, Icahn School of Medicine at Mount Sinai, New York, United States of America

  ⨯
• Ivan Spasojevic,

  Roles Investigation

  Affiliation Department of Medicine - Oncology, Duke University School of Medicine and PK/PD Core Laboratory, Duke Cancer Institute, Durham, North Carolina, United States of America

  ⨯
• Guo Hu,

  Roles Investigation

  Affiliations Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, United States of America, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America

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• Tammy Hennika,

  Roles Investigation

  Affiliations Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, United States of America, Genentech, Inc., South San Francisco, California,

  https://orcid.org/0000-0001-9264-6498

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• Daniel J. Brat,

  Roles Investigation

  Affiliation Department of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

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• Adam L. Green ,

  Roles Investigation

  * E-mail: oren.becher@mssm.edu (OJB); adam.green@cuanschutz.edu (AG)

  Affiliation Morgan Adams Foundation Pediatric Brain Tumor Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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•  [ ... ],
• Oren J. Becher

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: oren.becher@mssm.edu (OJB); adam.green@cuanschutz.edu (AG)

  Affiliations Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America, The Jack Martin Fund Division of Pediatric Hematology-Oncology, Mount Sinai Kravis Children’s Hospital, New York, New York, United States of America, Department of Oncological Sciences, Mount Sinai Health System, New York, New York, United States of America, Division of Hematology-Oncology and Stem Cell Transplant, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, Illinois, United States of America, Department of Biochemistry and Molecular Genetics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America

  https://orcid.org/0000-0003-4016-8492

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