Sex differences in alcohol inhibits bone formation and promotes bone resorption in young male and female rats by altering intestinal flora, metabolites, and bone microenvironment

• Ming Cheng ,

  Roles Data curation, Investigation, Writing – original draft

  ¶☯These authors contributed equally to this work and share first authorship.

  Affiliations School of Sports Medicine and Health, Chengdu Sport University, Sichuan, China, Department of Rehabilitation, Jinniu District People’s Hospital of Chengdu, Sichuan, China

  ⨯
• Hua Lu ,

  Roles Formal analysis, Investigation, Visualization

  ¶☯These authors contributed equally to this work and share first authorship.

  Affiliation Operating room, Sichuan Academy of Medical Sciences& Sichuan Provincial People’s Hospital, Sichuan, China

  ⨯
• Yangling Wu,

  Roles Visualization

  Affiliation Department of Rehabilitation, Jinniu District People’s Hospital of Chengdu, Sichuan, China

  ⨯
• Long Jia,

  Roles Visualization

  Affiliation Department of Rehabilitation, Jinniu District People’s Hospital of Chengdu, Sichuan, China

  ⨯
• Tao Xiang,

  Roles Formal analysis

  Affiliation Department of Rehabilitation, Jinniu District People’s Hospital of Chengdu, Sichuan, China

  ⨯
• L.i Deng,

  Affiliation Department of Orthopaedics, Sichuan Academy of Medical Sciences& Sichuan Provincial People’s Hospital, Sichuan, China

  ⨯
• Guanlan Zhao ,

  Roles Conceptualization, Methodology, Writing – review & editing

  * E-mail: zoezhao8311@163.com (G.-L. Z.), fjwdoc@163.com (J.-W. F.)

  Affiliation Department of Orthopaedics, Sichuan Academy of Medical Sciences& Sichuan Provincial People’s Hospital, Sichuan, China

  https://orcid.org/0000-0002-2354-7549

  ⨯
• Junwei Feng

  Roles Conceptualization, Methodology, Writing – review & editing

  * E-mail: zoezhao8311@163.com (G.-L. Z.), fjwdoc@163.com (J.-W. F.)

  Affiliation Department of Orthopaedics, Sichuan Academy of Medical Sciences& Sichuan Provincial People’s Hospital, Sichuan, China

  ⨯