Design, synthesis, in-vivo, and in-silico studies of 1,2,3-triazole tethered derivatives of morphine as novel anti-nociceptive agents

Faeze Nourmandipour; Reihane Emadi; Peyman Salehi; Mona Kamelan Zargar Zarin; Mona Khoramjouy; Amirreza Dowlati Beirami; Mehrdad Faizi

doi:10.1371/journal.pone.0323189

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Open Access

Peer-reviewed

Research Article

Design, synthesis, in-vivo, and in-silico studies of 1,2,3-triazole tethered derivatives of morphine as novel anti-nociceptive agents

Faeze Nourmandipour,

Roles Conceptualization, Investigation, Writing – original draft

Affiliation Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
⨯
Reihane Emadi,

Roles Conceptualization, Investigation, Writing – original draft

Affiliation Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
⨯
Peyman Salehi ,

Roles Formal analysis, Investigation, Project administration, Supervision, Writing – review & editing

* E-mail: p-salehi@sbu.ac.ir (PS); khoramjou@sbmu.ac.ir (MK)

Affiliation Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran

https://orcid.org/0000-0001-5774-3372

⨯
Mona Kamelan Zargar Zarin,

Roles Conceptualization, Investigation, Methodology

Affiliation Department of Phytochemistry, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, Tehran, Iran
⨯
Mona Khoramjouy ,

Roles Data curation, Investigation, Project administration, Writing – original draft

* E-mail: p-salehi@sbu.ac.ir (PS); khoramjou@sbmu.ac.ir (MK)

Affiliation Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
⨯
Amirreza Dowlati Beirami,

Roles Investigation, Software

Affiliations Department of Analytical Chemistry, Faculty of Chemistry, University of Vienna, Vienna, Austria, Department of Medicinal Chemistry, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

https://orcid.org/0000-0002-0691-8344

⨯
Mehrdad Faizi

Roles Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Department of Pharmacology and Toxicology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
⨯

Design, synthesis, in-vivo, and in-silico studies of 1,2,3-triazole tethered derivatives of morphine as novel anti-nociceptive agents

Faeze Nourmandipour,
Reihane Emadi,
Peyman Salehi,
Mona Kamelan Zargar Zarin,
Mona Khoramjouy,
Amirreza Dowlati Beirami,
Mehrdad Faizi

Published: June 16, 2025
https://doi.org/10.1371/journal.pone.0323189

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