Exploring the causal link between serum 25-hydroxyvitamin D concentrations and idiopathic sudden sensorineural hearing loss: Insights gained from a Mendelian randomization study involving two independent samples

Ying Zhao; Cong Yu; Hengchang Sun; Fangmei Xie; Jian Shen; Xiaoming Li; Xiaoyu Song; Wenfeng Luo; Jinhua He; Zeping Han

doi:10.1371/journal.pone.0322898

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Open Access

Peer-reviewed

Research Article

Exploring the causal link between serum 25-hydroxyvitamin D concentrations and idiopathic sudden sensorineural hearing loss: Insights gained from a Mendelian randomization study involving two independent samples

Ying Zhao ,

Contributed equally to this work with: Ying Zhao, Cong Yu, Hengchang Sun

Roles Investigation, Writing – original draft

Affiliation Central Laboratory, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China

https://orcid.org/0009-0004-7719-8374

⨯
Cong Yu ,

Contributed equally to this work with: Ying Zhao, Cong Yu, Hengchang Sun

Roles Writing – original draft

Affiliation Clinical Laboratory Department, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China
⨯
Hengchang Sun ,

Contributed equally to this work with: Ying Zhao, Cong Yu, Hengchang Sun

Roles Writing – review & editing

Affiliation Department of Laboratory Medcine, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, P.R. China
⨯
Fangmei Xie,

Roles Validation

Affiliation Central Laboratory, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China
⨯
Jian Shen,

Roles Visualization

Affiliation Central Laboratory, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China
⨯
Xiaoming Li,

Roles Data curation

Affiliation Clinical Laboratory Department, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China
⨯
Xiaoyu Song,

Roles Validation

Affiliation Central Laboratory, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China
⨯
Wenfeng Luo,

Roles Resources

Affiliation Central Laboratory, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China
⨯
Jinhua He,

Roles Writing – review & editing

Affiliation Central Laboratory, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China
⨯
Zeping Han

Roles Data curation

* E-mail: hanzeping1987@126.com

Affiliation Central Laboratory, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, Guangdong, P.R. China
⨯

Exploring the causal link between serum 25-hydroxyvitamin D concentrations and idiopathic sudden sensorineural hearing loss: Insights gained from a Mendelian randomization study involving two independent samples

Ying Zhao,
Cong Yu,
Hengchang Sun,
Fangmei Xie,
Jian Shen,
Xiaoming Li,
Xiaoyu Song,
Wenfeng Luo,
Jinhua He,
Zeping Han

Published: May 19, 2025
https://doi.org/10.1371/journal.pone.0322898

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Vitamin D
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Deafness
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Genome-wide association studies
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Single nucleotide polymorphisms
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Vitamin D deficiency
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