Leveraging transcriptome-wide association studies identifies the relationship between upper respiratory flora and cell type-specific gene expression in severe respiratory disease

Lei Xu; Ran He; Xiangyu Ye; Yifan Wang; Shirong Hui; Haochang Li; Hongbo Chen; Peng Huang

doi:10.1371/journal.pone.0322864

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Open Access

Peer-reviewed

Research Article

Leveraging transcriptome-wide association studies identifies the relationship between upper respiratory flora and cell type-specific gene expression in severe respiratory disease

Lei Xu ,

Roles Writing – original draft

¶‡ These authors share first authorship on this work.

Affiliation Depatment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platiorm, Nanjing Medical University, Nanjing, China
⨯
Ran He ,

Roles Supervision

¶‡ These authors share first authorship on this work.

Affiliation Depatment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platiorm, Nanjing Medical University, Nanjing, China
⨯
Xiangyu Ye,

Roles Data curation, Resources

Affiliation Depatment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platiorm, Nanjing Medical University, Nanjing, China
⨯
Yifan Wang ,

Roles Supervision

* E-mail: 18752942998@163.com (YW); chb2180@126.com (HC); huangpeng@njmu.edu.cn (PH)

Affiliation Department of Infectious Disease, Jurong Hospital Affiliated to Jiangsu University, Jurong, Jiangsu, China
⨯
Shirong Hui,

Roles Supervision

Affiliation Depatment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platiorm, Nanjing Medical University, Nanjing, China
⨯
Haochang Li,

Roles Supervision

Affiliation Depatment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platiorm, Nanjing Medical University, Nanjing, China
⨯
Hongbo Chen ,

Roles Supervision

* E-mail: 18752942998@163.com (YW); chb2180@126.com (HC); huangpeng@njmu.edu.cn (PH)

Affiliation Department of Infectious Disease, Jurong Hospital Affiliated to Jiangsu University, Jurong, Jiangsu, China
⨯
Peng Huang

Roles Supervision

* E-mail: 18752942998@163.com (YW); chb2180@126.com (HC); huangpeng@njmu.edu.cn (PH)

Affiliation Depatment of Epidemiology, Center for Global Health, School of Public Health, National Vaccine Innovation Platiorm, Nanjing Medical University, Nanjing, China

https://orcid.org/0000-0002-0146-921X

⨯

Leveraging transcriptome-wide association studies identifies the relationship between upper respiratory flora and cell type-specific gene expression in severe respiratory disease

Lei Xu,
Ran He,
Xiangyu Ye,
Yifan Wang,
Shirong Hui,
Haochang Li,
Hongbo Chen,
Peng Huang

Published: May 9, 2025
https://doi.org/10.1371/journal.pone.0322864

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