Causal relationship between schizophrenia and five types of dementia: A bidirectional two-sample Mendelian randomization study

Feng Tao; Shizhe Deng; Bifang Zhuo; Jingyue Liu; Xuan Liang; Jiangwei Shi; Zhihong Meng

doi:10.1371/journal.pone.0322752

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Open Access

Peer-reviewed

Research Article

Causal relationship between schizophrenia and five types of dementia: A bidirectional two-sample Mendelian randomization study

Feng Tao ,

Contributed equally to this work with: Feng Tao, Shizhe Deng, Bifang Zhuo

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Shizhe Deng ,

Contributed equally to this work with: Feng Tao, Shizhe Deng, Bifang Zhuo

Roles Conceptualization, Data curation, Writing – original draft

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Bifang Zhuo ,

Contributed equally to this work with: Feng Tao, Shizhe Deng, Bifang Zhuo

Roles Investigation, Visualization, Writing – original draft

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Jingyue Liu,

Roles Investigation, Visualization

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Xuan Liang,

Roles Investigation, Visualization

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Jiangwei Shi ,

Roles Supervision, Writing – review & editing

* E-mail: profmengzhihong@163.com (ZM); acustone@163.com (JS)

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China
⨯
Zhihong Meng

Roles Supervision, Writing – review & editing

* E-mail: profmengzhihong@163.com (ZM); acustone@163.com (JS)

Affiliations First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China

https://orcid.org/0000-0003-1397-3138

⨯

Causal relationship between schizophrenia and five types of dementia: A bidirectional two-sample Mendelian randomization study

Feng Tao,
Shizhe Deng,
Bifang Zhuo,
Jingyue Liu,
Xuan Liang,
Jiangwei Shi,
Zhihong Meng

Published: May 8, 2025
https://doi.org/10.1371/journal.pone.0322752

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Schizophrenia
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Alzheimer's disease
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Genome-wide association studies
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Single nucleotide polymorphisms
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