Cardamonin suppresses mTORC1/SREBP1 through reducing Raptor and inhibits de novo lipogenesis in ovarian cancer

• Peiguang Niu ,

  Contributed equally to this work with: Peiguang Niu, Danyun Li

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Department of Pharmacy, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China, Fujian Key Laboratory of Women and Children’s Critical Diseases Research [Fujian Maternity and Child Health Hospital (Fujian Women and Children’s Hospital)], Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China

  https://orcid.org/0000-0002-9262-9716

  ⨯
• Danyun Li ,

  Contributed equally to this work with: Peiguang Niu, Danyun Li

  Roles Funding acquisition, Investigation, Methodology, Visualization

  Affiliation Department of Pharmacy, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China

  ⨯
• Huajiao Chen,

  Roles Data curation, Formal analysis, Validation

  Affiliation Department of Pharmacy, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China

  https://orcid.org/0009-0009-1622-933X

  ⨯
• Yanting Zhu,

  Roles Data curation, Formal analysis, Validation

  Affiliations Department of Pharmacy, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China, Fujian Key Laboratory of Women and Children’s Critical Diseases Research [Fujian Maternity and Child Health Hospital (Fujian Women and Children’s Hospital)], Fujian Maternity and Child Health Hospital, Fuzhou, Fujian, China

  ⨯
• Jintuo Zhou,

  Roles Data curation, Formal analysis, Validation

  Affiliation Department of Pharmacy, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China

  ⨯
• Jinhua Zhang ,

  Roles Conceptualization, Project administration, Supervision

  * E-mail: fjliuying@fjmu.edu.cn (YL); pollyzhang2006@fjmu.edu.cn (JZ)

  ¶‡ JZ and YL also contributed equally to this work.

  Affiliation Department of Pharmacy, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China

  ⨯
• Ying Liu

  Roles Investigation, Methodology, Visualization

  * E-mail: fjliuying@fjmu.edu.cn (YL); pollyzhang2006@fjmu.edu.cn (JZ)

  ¶‡ JZ and YL also contributed equally to this work.

  Affiliation Department of Pharmacy, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, China

  ⨯