Broussonetia papyrifera ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by modulating the TLR4/NF-κB and PI3K/AKT signaling pathways

Xiaoqiang Huang; Li Wang; Xiaoying Ma; Shunhe Liu; Hongchang Zhao; Pengbo Zhang; Liyan Li; Wanli Zhao; An Jia

doi:10.1371/journal.pone.0322710

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Open Access

Peer-reviewed

Research Article

Broussonetia papyrifera ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by modulating the TLR4/NF-κB and PI3K/AKT signaling pathways

Xiaoqiang Huang ,

Contributed equally to this work with: Xiaoqiang Huang, Li Wang, Xiaoying Ma

Roles Investigation

Affiliation School of Medicine, Huanghe Science & Technology University, Zhengzhou, China
⨯
Li Wang ,

Contributed equally to this work with: Xiaoqiang Huang, Li Wang, Xiaoying Ma

Roles Methodology

Affiliation School of Medicine, Huanghe Science & Technology University, Zhengzhou, China
⨯
Xiaoying Ma ,

Contributed equally to this work with: Xiaoqiang Huang, Li Wang, Xiaoying Ma

Roles Investigation

Affiliations School of Medicine, Huanghe Science & Technology University, Zhengzhou, China, School of Pharmacy, Henan University, Kaifeng, China
⨯
Shunhe Liu,

Roles Writing – review & editing

Affiliation School of Medicine, Huanghe Science & Technology University, Zhengzhou, China
⨯
Hongchang Zhao,

Roles Software

Affiliations School of Medicine, Huanghe Science & Technology University, Zhengzhou, China, School of Pharmacy, Henan University, Kaifeng, China
⨯
Pengbo Zhang,

Roles Software

Affiliations School of Medicine, Huanghe Science & Technology University, Zhengzhou, China, School of Pharmacy, Henan University, Kaifeng, China
⨯
Liyan Li,

Roles Methodology

Affiliation School of Medicine, Huanghe Science & Technology University, Zhengzhou, China
⨯
Wanli Zhao ,

Roles Conceptualization, Writing – review & editing

* E-mail: 201208120@hhstu.edu.cn (AJ); zwl20150728@126.com (WZ)

Affiliations School of Medicine, Huanghe Science & Technology University, Zhengzhou, China, Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden, Mem. Sun Yat-Sen), Nanjing, China

https://orcid.org/0000-0002-5581-893X

⨯
An Jia

Roles Project administration

* E-mail: 201208120@hhstu.edu.cn (AJ); zwl20150728@126.com (WZ)

Affiliation School of Medicine, Huanghe Science & Technology University, Zhengzhou, China
⨯

Broussonetia papyrifera ameliorates imiquimod-induced psoriasis-like skin inflammation in mice by modulating the TLR4/NF-κB and PI3K/AKT signaling pathways

Xiaoqiang Huang,
Li Wang,
Xiaoying Ma,
Shunhe Liu,
Hongchang Zhao,
Pengbo Zhang,
Liyan Li,
Wanli Zhao,
An Jia

Published: May 7, 2025
https://doi.org/10.1371/journal.pone.0322710

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