Bulk and single-cell RNA-sequencing analyses revealed potential key genes and the role of CCL19/CCL21-CCR7 axis in hidradenitis suppurativa

Xiaodong Lai; Yan Yang; Haini Zhang; Chong Zhang; Meng Wang; Wanxin Chen; Baoxi Wang; Yan Yan

doi:10.1371/journal.pone.0322565

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Open Access

Peer-reviewed

Research Article

Bulk and single-cell RNA-sequencing analyses revealed potential key genes and the role of CCL19/CCL21-CCR7 axis in hidradenitis suppurativa

Xiaodong Lai ,

Contributed equally to this work with: Xiaodong Lai, Yan Yang

Roles Conceptualization, Software, Writing – original draft

Affiliation Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

https://orcid.org/0000-0001-7991-2237

⨯
Yan Yang ,

Contributed equally to this work with: Xiaodong Lai, Yan Yang

Roles Conceptualization, Visualization

Affiliation Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

https://orcid.org/0000-0003-4336-1538

⨯
Haini Zhang,

Roles Methodology, Software

Affiliation Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Chong Zhang,

Roles Methodology

Affiliation Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Meng Wang,

Roles Validation

Affiliation Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Wanxin Chen,

Roles Validation

Affiliation Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Baoxi Wang,

Roles Conceptualization, Project administration, Supervision

Affiliation Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯
Yan Yan

Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – review & editing

* E-mail: yanyan@psh.pumc.edu.cn

Affiliation Department of Dermatology, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
⨯

Bulk and single-cell RNA-sequencing analyses revealed potential key genes and the role of CCL19/CCL21-CCR7 axis in hidradenitis suppurativa

Xiaodong Lai,
Yan Yang,
Haini Zhang,
Chong Zhang,
Meng Wang,
Wanxin Chen,
Baoxi Wang,
Yan Yan

Published: June 2, 2025
https://doi.org/10.1371/journal.pone.0322565

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