β-aminopropionitrile-induced thoracic aortopathy is refractory to cilostazol and sildenafil in mice

Samuel C. Tyagi; Sohei Ito; Jacob C. Hubbuch; Michael K. Franklin; Deborah A. Howatt; Hong S. Lu; Alan Daugherty; Hisashi Sawada

doi:10.1371/journal.pone.0322434

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Peer-reviewed

Research Article

β-aminopropionitrile-induced thoracic aortopathy is refractory to cilostazol and sildenafil in mice

Samuel C. Tyagi,

Roles Data curation, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

Affiliations Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Saha Aortic Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Department of Surgery, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Sohei Ito,

Roles Data curation, Writing – review & editing

Affiliations Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Saha Aortic Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Jacob C. Hubbuch,

Roles Data curation

Affiliations Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Saha Aortic Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Department of Surgery, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Michael K. Franklin,

Roles Data curation

Affiliations Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Saha Aortic Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Deborah A. Howatt,

Roles Data curation

Affiliations Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Saha Aortic Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Hong S. Lu,

Roles Supervision, Validation, Writing – review & editing

Affiliations Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Saha Aortic Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

https://orcid.org/0000-0002-0577-2558

⨯
Alan Daugherty ,

Roles Funding acquisition, Supervision, Validation, Writing – review & editing

* E-mail: hisashi.sawada@uky.edu (HS); Alan.Daugherty@uky.edu (AD)

Affiliations Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Saha Aortic Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

https://orcid.org/0000-0003-2093-3775

⨯
Hisashi Sawada

Roles Formal analysis, Funding acquisition, Supervision, Validation, Visualization, Writing – original draft

* E-mail: hisashi.sawada@uky.edu (HS); Alan.Daugherty@uky.edu (AD)

Affiliations Saha Cardiovascular Research Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Saha Aortic Center, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America, Department of Physiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

https://orcid.org/0000-0003-0017-6236

⨯

β-aminopropionitrile-induced thoracic aortopathy is refractory to cilostazol and sildenafil in mice

Samuel C. Tyagi,
Sohei Ito,
Jacob C. Hubbuch,
Michael K. Franklin,
Deborah A. Howatt,
Hong S. Lu,
Alan Daugherty,
Hisashi Sawada

Published: August 29, 2025
https://doi.org/10.1371/journal.pone.0322434

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