Harmonizing CT scanner acquisition variability in an anthropomorphic phantom: A comparative study of image-level and feature-level harmonization using GAN, ComBat, and their combination

Shruti Atul Mali; Nastaran Mohammadian Rad; Henry C. Woodruff; Adrien Depeursinge; Vincent Andrearczyk; Philippe Lambin

doi:10.1371/journal.pone.0322365

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Open Access

Peer-reviewed

Research Article

Harmonizing CT scanner acquisition variability in an anthropomorphic phantom: A comparative study of image-level and feature-level harmonization using GAN, ComBat, and their combination

Shruti Atul Mali ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

* E-mail: s.mali@maastrichtuniversity.nl

Affiliation The D-Lab, Department of Precision Medicine, GROW- Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands

https://orcid.org/0000-0002-8307-8051

⨯
Nastaran Mohammadian Rad,

Roles Conceptualization, Formal analysis, Investigation, Supervision, Validation, Writing – review & editing

Affiliation The D-Lab, Department of Precision Medicine, GROW- Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands
⨯
Henry C. Woodruff,

Roles Funding acquisition, Investigation, Supervision, Writing – review & editing

Affiliations The D-Lab, Department of Precision Medicine, GROW- Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands, Department of Radiology and Nuclear Medicine, GROW- Research Institute School for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, Netherlands

https://orcid.org/0000-0001-7911-5123

⨯
Adrien Depeursinge,

Roles Formal analysis, Investigation, Validation, Writing – review & editing

Affiliations Institute of Information Systems, University of Applied Sciences and Arts Western Switzerland, Sierre, Switzerland, Department of Nuclear Medicine and Molecular Imaging, Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
⨯
Vincent Andrearczyk,

Roles Formal analysis, Investigation, Validation, Writing – review & editing

Affiliation Institute of Information Systems, University of Applied Sciences and Arts Western Switzerland, Sierre, Switzerland
⨯
Philippe Lambin

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliations The D-Lab, Department of Precision Medicine, GROW- Research Institute for Oncology and Reproduction, Maastricht University, Maastricht, Netherlands, Department of Radiology and Nuclear Medicine, GROW- Research Institute School for Oncology and Reproduction, Maastricht University Medical Centre+, Maastricht, Netherlands
⨯

Harmonizing CT scanner acquisition variability in an anthropomorphic phantom: A comparative study of image-level and feature-level harmonization using GAN, ComBat, and their combination

Shruti Atul Mali,
Nastaran Mohammadian Rad,
Henry C. Woodruff,
Adrien Depeursinge,
Vincent Andrearczyk,
Philippe Lambin

Published: May 9, 2025
https://doi.org/10.1371/journal.pone.0322365

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