Drug–drug interactions between epidermal growth factor receptor tyrosine kinase inhibitors and rivaroxaban in vitro and in vivo

Dongxu Wang; Shuanghu Wang; Hualan Wu; Peiwu Geng; Yang An; Xiaoyue Zhou; Minghui Du; Yuwei Li; Jia Chong; Yingying Li; Fang Wang; Zebei Lu; Yu Wang; Jiefu Yang; Chuanbao Li; Dapeng Dai; Hao Chen

doi:10.1371/journal.pone.0322303

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Open Access

Peer-reviewed

Research Article

Drug–drug interactions between epidermal growth factor receptor tyrosine kinase inhibitors and rivaroxaban in vitro and in vivo

Dongxu Wang ,

Contributed equally to this work with: Dongxu Wang, Shuanghu Wang

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft

Affiliations Department of Cardiovascular, Beijing Hospital, National Centre of Gerontology, Beijing, China, Arrhythmia Center, Fuwai Hospital, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases, Beijing, China
⨯
Shuanghu Wang ,

Contributed equally to this work with: Dongxu Wang, Shuanghu Wang

Roles Conceptualization, Funding acquisition, Investigation, Supervision

Affiliation Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People’s Hospital of Lishui, Lishui, Zhejing, China
⨯
Hualan Wu,

Roles Investigation, Writing – review & editing

Affiliation Department of Cardiovascular, Beijing Hospital, National Centre of Gerontology, Beijing, China
⨯
Peiwu Geng,

Roles Methodology, Project administration, Software

Affiliation Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People’s Hospital of Lishui, Lishui, Zhejing, China
⨯
Yang An,

Roles Methodology, Writing – review & editing

Affiliation Department of Cardiovascular, Beijing Hospital, National Centre of Gerontology, Beijing, China
⨯
Xiaoyue Zhou,

Roles Investigation, Resources, Validation

Affiliation Department of Cardiovascular, Beijing Hospital, National Centre of Gerontology, Beijing, China
⨯
Minghui Du,

Roles Investigation, Validation

Affiliation Department of Cardiovascular, Beijing Hospital, National Centre of Gerontology, Beijing, China
⨯
Yuwei Li,

Roles Validation, Writing – review & editing

Affiliation Department of Cardiovascular, Beijing Hospital, National Centre of Gerontology, Beijing, China
⨯
Jia Chong,

Roles Resources, Validation

Affiliation Department of Cardiovascular, Beijing Hospital, National Centre of Gerontology, Beijing, China
⨯
Yingying Li,

Roles Investigation, Validation

Affiliation Department of Cardiovascular, Beijing Hospital, National Centre of Gerontology, Beijing, China
⨯
Fang Wang,

Roles Supervision

Affiliation Department of Cardiovascular, Beijing Hospital, National Centre of Gerontology, Beijing, China
⨯
Zebei Lu,

Roles Formal analysis, Validation, Visualization

Affiliation Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People’s Hospital of Lishui, Lishui, Zhejing, China
⨯
Yu Wang,

Roles Formal analysis, Methodology

Affiliation Laboratory of Clinical Pharmacy, The Sixth Affiliated Hospital of Wenzhou Medical University, The People’s Hospital of Lishui, Lishui, Zhejing, China
⨯
Jiefu Yang,

Roles Supervision

Affiliation Department of Cardiovascular, Beijing Hospital, National Centre of Gerontology, Beijing, China
⨯
Chuanbao Li,

Roles Supervision

Affiliation Department of Clinical Laboratory, Beijing Hospital, National Center of Gerontology, Beijing, China
⨯
Dapeng Dai ,

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: dr.chenhaomd_bjh@vip.163.com

Affiliation The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Centre of Gerontology, Beijing, China
⨯
[ ... ],
Hao Chen

Roles Conceptualization, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: dr.chenhaomd_bjh@vip.163.com

Affiliation Department of Cardiovascular, Beijing Hospital, National Centre of Gerontology, Beijing, China

https://orcid.org/0000-0002-4488-793X

⨯
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Drug–drug interactions between epidermal growth factor receptor tyrosine kinase inhibitors and rivaroxaban in vitro and in vivo

Dongxu Wang,
Shuanghu Wang,
Hualan Wu,
Peiwu Geng,
Yang An,
Xiaoyue Zhou,
Minghui Du,
Yuwei Li,
Jia Chong,
Yingying Li

Published: June 3, 2025
https://doi.org/10.1371/journal.pone.0322303

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