PTPN21 inhibits cell apoptosis of acute lymphoblastic leukemia induced by chemotherapeutic agents via GADD45A and JNK signaling pathway

Chenze Zhao; Yu Zhang; Linlin Huang; Jingjing Xiang; Baodong Ye; Ni Zhu

doi:10.1371/journal.pone.0322273

Loading metrics

Open Access

Peer-reviewed

Research Article

PTPN21 inhibits cell apoptosis of acute lymphoblastic leukemia induced by chemotherapeutic agents via GADD45A and JNK signaling pathway

Chenze Zhao,

Roles Formal analysis, Funding acquisition, Writing – original draft

Affiliation Heart Center, Department of Cardiovascular Medicine, Zhejiang Provincial People’s Hospital, Affiliated People’s Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China
⨯
Yu Zhang,

Roles Conceptualization, Investigation, Validation

Affiliation Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China
⨯
Linlin Huang,

Roles Investigation, Project administration

Affiliation Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China
⨯
Jingjing Xiang,

Roles Investigation, Methodology, Validation

Affiliation Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China
⨯
Baodong Ye,

Roles Conceptualization, Supervision, Validation, Writing – review & editing

Affiliation Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China
⨯
Ni Zhu

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Validation, Writing – review & editing

* E-mail: zn_delia28@126.com

Affiliation Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China

https://orcid.org/0000-0002-3418-3365

⨯

PTPN21 inhibits cell apoptosis of acute lymphoblastic leukemia induced by chemotherapeutic agents via GADD45A and JNK signaling pathway

Chenze Zhao,
Yu Zhang,
Linlin Huang,
Jingjing Xiang,
Baodong Ye,
Ni Zhu

Published: April 30, 2025
https://doi.org/10.1371/journal.pone.0322273

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Apoptosis
Is the Subject Area "Apoptosis" applicable to this article?

Thanks for your feedback.
Acute lymphoblastic leukemia
Is the Subject Area "Acute lymphoblastic leukemia" applicable to this article?

Thanks for your feedback.
c-Jun N-terminal kinase signaling cascade
Is the Subject Area "c-Jun N-terminal kinase signaling cascade" applicable to this article?

Thanks for your feedback.
Phosphorylation
Is the Subject Area "Phosphorylation" applicable to this article?

Thanks for your feedback.
Hyperexpression techniques
Is the Subject Area "Hyperexpression techniques" applicable to this article?

Thanks for your feedback.
Cell cycle and cell division
Is the Subject Area "Cell cycle and cell division" applicable to this article?

Thanks for your feedback.
Flow cytometry
Is the Subject Area "Flow cytometry" applicable to this article?

Thanks for your feedback.
Transfection
Is the Subject Area "Transfection" applicable to this article?

Thanks for your feedback.