DERL3 facilitates the progression of clear cell renal cell carcinoma by promoting epithelial-mesenchymal transition via regulation of the TGFB1 pathway

Chengtao Niu; Haodong Cui; Xintong Sun; Yuchang Yang; Xue Jiang; Zixiang Cong; Yiming Zhang; Zhihong Niu; Wei He

doi:10.1371/journal.pone.0322172

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Open Access

Peer-reviewed

Research Article

DERL3 facilitates the progression of clear cell renal cell carcinoma by promoting epithelial-mesenchymal transition via regulation of the TGFB1 pathway

Chengtao Niu,

Roles Writing – original draft

Affiliations Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China, Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

https://orcid.org/0000-0002-5218-7511

⨯
Haodong Cui,

Roles Data curation

Affiliations Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China, Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
⨯
Xintong Sun,

Roles Data curation

Affiliation Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
⨯
Yuchang Yang,

Roles Data curation

Affiliation Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
⨯
Xue Jiang,

Roles Data curation

Affiliation Shandong Xiehe University, Jinan, China
⨯
Zixiang Cong,

Roles Data curation

Affiliation Department of Urology, Weihai Municipal Hospital Affiliated to Shandong University, Weihai, China
⨯
Yiming Zhang,

Roles Data curation

Affiliation Department of Urology, People’s Hospital of Changle County, Weifang, Shandong, China
⨯
Zhihong Niu ,

Roles Data curation

* E-mail: hewei@bjmu.edu.cn (WH); nzh1789@163.com (ZN)

Affiliations Department of Urology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China, Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China
⨯
Wei He

Roles Supervision

* E-mail: hewei@bjmu.edu.cn (WH); nzh1789@163.com (ZN)

Affiliation Department of Urology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China

https://orcid.org/0000-0002-4272-2891

⨯

DERL3 facilitates the progression of clear cell renal cell carcinoma by promoting epithelial-mesenchymal transition via regulation of the TGFB1 pathway

Chengtao Niu,
Haodong Cui,
Xintong Sun,
Yuchang Yang,
Xue Jiang,
Zixiang Cong,
Yiming Zhang,
Zhihong Niu,
Wei He

Published: April 29, 2025
https://doi.org/10.1371/journal.pone.0322172

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Cytoskeletal proteins
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Hyperexpression techniques
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Endoplasmic reticulum
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Renal cancer
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Gene expression
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Renal cell carcinoma
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